Acquisition of Wide Bore Nuclear Magnetic Resonance Imager

圣母大学将购买一台磁共振成像设备，用于生物科学系、化学与生物化学系、化学工程系、电子工程系和物理系的研究。研究问题包括研究泡沫的演化、结构及其流变性的时间依赖性；包括泡沫在内的液体在多孔介质中的流动；浓悬浮液的流动成像及其性质神经网络的体系结构为这些网络的数学建模提供了信息源；冬眠心肌和富马酸还原酶对厌氧症和代谢改变的研究选择性MRI造影剂的设计以及作为代谢反应的组织冷冻和冷冻保护剂分布的研究。从这些研究中获得的结果将支持电子工程系的OLISAO项目的研究，该项目发展理论和数值模拟来拟合和处理图像信号。这些研究从理论到应用各不相同，从工程设计到神经生物学。LISA的支持将有助于开发改进的成像技术，提高将数据处理成图像的速度和准确性。所提出的研究要么需要对制备的样品进行静态成像，要么需要研究图像随时间的变化。这些项目都可以用一个垂直的、高分辨率的核磁共振成像光谱仪在300兆赫（7特斯拉磁场）下工作，并配备必要的附件来获取和处理数据。体内探针（64mm工作直径）可在20 G/cm （40 A）梯度强度下监测1H，适用于蛙体高分辨率三维成像实验和大规模流体力学实验。微成像探针将有0.4厘米到2.5厘米的线圈，可用于各种核，微成像探针的分辨率低于100微米，可用于高分辨率材料科学和生物化学实验。一些硬件和软件将需要为个别实验定制设计。三名核磁共振专家将出现在核磁共振设施中，其中一名专门从事核磁共振，另一名具有丰富的核磁共振经验，为实验开发和执行提供支持。现有教职工10人，博士后5人，研究生12人，本科生5人。MRI还将用于约65人的本科课程和每年约25人的研究生课程。＊＊＊

9601691 Glazier The University of Notre Dame will purchase a Magnetic Resonance Imaging (MRI) to pursue research in the department of Biological Sciences, Chemistry and Biochemistry, Chemical Engineering, Electrical Engineering and Physics. Research problems include the study of the evolution of foams, their structures and the time dependence of their rheology; the flow of liquids including foams in porous media; the imaging of flow in concentrated suspensions and their properties; the architecture of neural network as a source of information for the mathematical modeling of these networks; hibernating myocardium and fumarate reductase as a study of anaerobiosis and metabolic alteration; the design of selective MRI contrast agents and studies of tissue freezing and cryoprotectant distribution as a metabolic response. The results obtained from these studies will support the research of the OLISAO program in the Department of Electrical Engineering which develops theory and numerical simulations to fit and process image signals. These studies vary from theoretical to applied and form engineering design to neurobiology. The support from LISA will aid in developing improved imaging technology and increase speed and accuracy in processing of data into images. The proposed studies either require static imaging of prepared samples or study of the changes of images in time. These projects can all be adequately performed with a vertical, high resolution NMR imagine spectrometer operating at 300 MHz (7 Tesla magnetic field) with the necessary accessories to acquire and process data. The in-vivo probe (64mm working diameter) will monitor 1H at gradient strengths of 20 G/cm (at 40 A), suitable for high resolution 3-d imaging experiments on frog and for large scale hydrodynamics experiments. The microimaging probe will be available with 0.4 cm to 2.5 cm coils for various nuclei, with microprobes for microimaging at a resolution below 100 um for use in high resolution materials science and bioc hemistry experiments. Some of the hardware and software will require custom design for individual experiments. Three NMR specialists will be present in the NMR facility, one devoted solely to MRI and one with extensive MRI experience, to provide support for experiment development and execution. The current proposal includes 10 faculty, 5 postdoctoral, 12 graduate students and 5 undergraduate researchers. MRI will also be used in undergraduate courses with an enrollment of about 65 and graduate courses with an annual enrollment of about 25. ***