Development of EB/TOF Mass Spectrometer with CID and SID Capabilities

学术研究基础设施(ARI)计划的这一奖项将帮助亚利桑那大学化学系获得具有电子扇区(E)-磁扇区(B)/曲场反射飞行时间(TOF)几何结构的混合质谱仪(MS)。该设备将加强以下领域的研究：(1)设计和合成各种具有生物活性的线状和环状多肽、假肽、多肽模拟学和复合肽文库(2)血红素和血红素蛋白中的结构/物理性质/反应性关系(3)酶和模拟酶的钼和血红素中心特征的化合物的研究(4)新有机化合物的合成和表征(5)基于碳水化合物的天然产物类似物的合成和新型碳水化合物的材料的开发(6)新型两亲性分子的设计和合成，这些分子在溶剂化时形成有组织的组装(7)合成新材料的新的有机合成方法，以及(8)昆虫中脂质运输的机制。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。

This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry at the University of Arizona acquire a hybrid mass spectrometer (MS) with an electric sector (E)-magnetic sector(B)/curved field reflection time-of-flight (TOF) geometry. This equipment will enhance research in a number of areas including the following: (1) design and synthesis of a variety of biologically active linear and cyclic peptides, pseudopeptides, peptidomimetics and complex peptide libraries (2) structure/physical property/reactivity relationships in hemes and heme proteins (3) studies of the enzyme and compounds that mimic features of the molybdenum and heme centers of the enzyme (4) synthesis and characterization of new organic compounds (5) synthesis of carbohydrate based natural product analogs and the development of novel carbohydrate based materials (6) design and synthesis of novel amphiphilic molecules that form organized assemblies upon solvation (7) novel organic snthesis methodology to synthesis of novel materials, and (8) mechanism of lipid transport in insects. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.