Transitions in Bulk and Mesoscopic Liquids

9602884 C.奥斯汀·安吉尔 “散装和介观液体的转变” 该奖学金将为C教授在澳大利亚悉尼大学为期六个月的访问中的三个月提供部分支持。亚利桑那州立大学物理系的奥斯汀·安吉尔说。 Angell教授将与P. Harrowell教授和G. Warr对当前玻璃化转变的动力学和热力学方面，或多晶玻璃和液体系统，以及这种多晶与介观系统中主要结构转变的关系，如蛋白质和RNA折叠转变。 Angell对玻璃化转变现象学的兴趣将与Harrowell在动力学伊辛模型方面的理论专长相结合，以及随后的液体脆性的微观起源，以及Warr在微乳液结构和稳定性方面的经验，以提高目前对玻璃和玻璃和生物聚合物中的多晶性的理解。 研究人员将1）在恒定化学势下控制系统尺寸，以观察系统尺寸效应，特别是在尺寸与归因于微不均匀性的那些尺寸相当的系统中，微不均匀性现在似乎出现在玻璃温度附近; 2）基于促进的自旋微观非均相模型进行理论研究，以确定产生涂抹的必要条件，水合蛋白质系统的玻璃-液体转化特性; 3）进行蛋白质重折叠动力学的多步量热研究，以评估成核和生长动力学与一级复杂系统转变的相关性;以及4）利用微乳液技术来检查限制对折叠动力学的影响，并探索单分子观察策略。

9602884 C. Austen Angell "Transitions in Bulk and Mesoscopic Liquids" This award will provide partial support for three months of a six month visit to the University of Sydney, Australia, by Professor C. Austen Angell of the Department of Physics, Arizona State University. Professor Angell will conduct collaborative research with Professors P. Harrowell and G. Warr on current aspects of the dynamics and thermodynamics of the glass transition, or polyamorphism glassy and liquid systems, and of the relation of such polyamorphism to major structural transitions in mesoscopic systems such as protein and RNA folding transitions. Angell's interest in glass transition phenomenology will be combined with Harrowell's theoretical expertise in kinetic Ising models, and the consequent microscopic origins of liquid fragility, and Warr's experience in microemulsion structure and stability, to improve current understanding of glasses and polyamorphism in glasses and biopolymers. The investigators will 1) use control of system size at constant chemical potential to see system size effects, in particular in systems with dimensions comparable to those attributed to microheterogeneities which now seem to appear near the glass temperature; 2) perform theoretical studies based on a facilitated spin microheterogeneous model to determine the conditions necessary to produce the smeared-out, glass- liquid transformation characteristic of hydrated protein systems; 3) undertake multi-step calorimetric studies of protein refolding kinetics to assess the relevance of nucleation and growth kinetics to the first order complex systems transition; and 4) utilize microemulsion techniques to examine effects of confinement on folding kinetics and to explore single molecule observation strategies.