U.S.-Chile Cooperative Research: Role of IP3-Receptor in Visual Transduction

9604977 O‘Day这个美洲计划奖将资助俄勒冈大学的Peter O’Day博士和智利大学的Juan Bacigalupo博士之间为期3年的合作研究项目，研究IP3受体在视觉转导中的作用，视觉转导是产生视觉兴奋的视网膜生物化学的协调。研究人员将重点研究两个特定的生化信号通路如何在果蝇视网膜细胞的视觉转导中相互作用的问题。这两个通路之间的直接相互作用是否是转导的基础是一个重要的问题，其研究可能为其他转导系统提供模型。研究人员打算使用生物物理和生化方法结合突变分析来检查这种联系。这项拟议的工作非常重要，不仅对于理解无脊椎动物视觉转导的生物化学编排，而且对于揭示信号转导的一些基本问题也是重要的。合作将促进科学信息、技术和策略的交流，从而加强和拓宽两个小组长期计划可用的实验方法。***

9604977 O'Day This Americas Program award will fund a 3-year cooperative research project between Dr. Peter O'Day, University of Oregon, and Dr. Juan Bacigalupo, University of Chile, on a study of the role of IP3-Receptor in visual transduction, the orchestration of retinal biochemistry that generates visual excitation. The investigators will focus on the question of how two specific biochemical signaling pathways interact in visual transduction in retinal cells from Drosophila. Whether direct interaction between the two pathways is fundamental to transduction is an important question whose examination may provide models for other transducing systems. The researchers intend to use biophysical and biochemical approaches with mutational analysis to examine the connection. The proposed work is important, not only for understanding the biochemical orchestration of invertebrate visual transduction, but also for bringing out some fundamental issues of signal transduction The collaboration will facilitate the exchange of scientific information, technologies, and strategies, thereby enhancing and broadening the experimental approaches available for the long term programs of both groups. ***