Nucleation of Protein Crystals

提案号：9612223提案类型：研究计划拨款首席研究员：Constance A. Schall隶属关系：塔尔萨大学研究者建议在蛋白质晶体成核领域开展研究。这是一个重要的领域，在蛋白质纯化、结构测定等方面有着巨大的应用。然而，在很大程度上，蛋白质结晶仍然是一门艺术，重要的是，新的研究人员为这种现象带来科学依据，从而允许技术开发。本阶段研究经验和成熟度优秀的研究者资质。机构设施是适当的，但是大学没有通过为PI提供启动包来鼓励研究活动。令人失望的是，PI甚至必须从拨款中购买基本的研究仪器（混合器，分析天平）；该机构本应在这方面提供帮助。然而，这是一位值得尊敬的PI，她在研究生工作中表现出了希望，这笔资助应该促进她的研究事业的发展。计划官员建议资助此提案。

Proposal No: 9612223 Proposal Type: Research Planning Grant Principal Investigator: Constance A. Schall Affiliation: University of Tulsa The investigator proposes to initiate research in the area of nucleation of protein crystals. This is an important area with tremendous applications in protein purification, structure determination etc. However, protein crystallization is still an art, to a large extent, and it is important that new researchers bring scientific rationales to the phenomenon thereby allowing technological exploitation. The investigator qualifications are excellent at this stage of research experience and maturity. The institutional facilities are appropriate, but the university has not done much to encourage research activity by providing a start up package for the PI. It is disappointing that the PI has to purchase even basic research instrumentation (mixer, analytical balance) from the grant; the institution should have helped in this regard. Nevertheless, this is a worthy PI who has shown promise in her graduate work, and the grant should foster the development of her research career. The program officer recommends funding of this proposal.