Strategies for Designing Transition Metal-Based Catalysts: Use of Polymer Tertiary Structure to Control Inner and Outer Sphere Coordination Environments

本研究的重点是为以下方面开发方法： 制备用于催化合成的手性金属空腔。的 概念是通过模板方法将聚合物腔体构建到 其中金属可以被放置并用作手性催化剂。在这 方法，金属的外部和内部球环境 应控制催化剂。在这笔赠款的教育部分， 总体目标是将有机和有机金属化学整合到 课程、研究和研讨会。学生将撰写论文， 关于当前文学主题的讲座，包括这两个 子学科。 有效催化反应的能力为以下反应提供了基础： 将容易获得的有机材料转化为许多有用的 产品.对于医药产品，一个额外的功能是控制 手性拓扑结构。该研究项目由有机 动力学计划将通过设计手性聚合物来解决这个问题。 其中可以拴有手性金属催化剂的空腔。各种 将使用测试示例来演示概念实用程序。的 本次调查的教育部分将集中在整合 有机和有机化学。这将通过课程工作来完成， 本科生和研究生级别的研讨会和研究

The focus of this research is to develop methodologies for the preparation of chiral metallic cavities for catalytic synthesis. The concept is to build, via template methodology, a polymeric cavity into which a metal can be placed and used as a chiral catalyst. In this methodology, both the outer an inner sphere environments of the metal catalyst shall be controlled. In the education portion of this grant, the overall goal is to integrate organic and organometallic chemistry in courses, research and seminars. Students will write papers and give lectures on current literature topics which cover these two sub-disciplines. The ability to catalyze reactions efficiently provides the basis for transforming readily available organic materials into numerous useful products. For medicinal products, one additional feature is the control of chiral topology. This research project supported by the Organic Dynamics Program will address this issue by designing chiral polymeric cavities into which chiral metal catalysts can be tethered. A variety of test examples will be used to demonstrate the concept utility. The education portion of this investigation will focus on the integration of Organic and Organometallic chemistry. This will be done by course work, seminars and research at both the undergraduate and graduate level