Biophysical identification of natural human antibody targets

一种天然的人类抗体PAT-SM6使用合作伙伴组织(Patrys)开发的技术分离出来，有望作为一种治疗方法来减少癌症造成的死亡率，癌症是澳大利亚的主要死亡原因。Patrys首创的方法的新颖性是直接产生人类抗体，避免了与使用含有非人类成分的抗体相关的不良副作用。该项目旨在发现PAT-SM6对蛋白质和蛋白质复合体的特异性，以及这些相互作用如何导致肿瘤细胞死亡。这项工作将提高人类抗体疗法的有效性，并有助于澳大利亚生物技术行业这一快速增长领域的发展。

A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.