Analysis of the role of the B cell inhibitory receptor Siglec-G in autoimmunity and infection models

Siglec蛋白是免疫细胞上的一个抑制受体家族。我们最近将siglecg描述为这个家庭的新成员。siglece - g在B淋巴细胞上表达，在小鼠B1细胞亚群中作为抑制受体具有特异性作用。这在Siglec- g缺陷小鼠中发现，B1细胞大量扩增，B1细胞Ca2+反应增加。该提案将在剑桥大学实验室的研究访问期间研究siglece - g在全身自身免疫和抗菌免疫球蛋白反应中的作用。

Siglec proteins are a family of inhibitory receptors on immune cells. We recently characterized Siglec-G as a new member of this family. Siglec-G is expressed on B lymphocytes and has a specific role as inhibitory receptor on the B1 cell subset in the mouse. This was found in Siglec- G-deficient mice with have a large expansion of B1 cells and increased B1 cell Ca2+ responses. This proposal addresses the role of Siglec-G in systemic autoimmunity and anti-bacterial immunoglobulin responses which will be studied during a research visit in a lab at Cambridge University.