Career Advancement Award-Energetics and Mechanisms of Reductive Elimination Reactions

Karen Goldberg博士，华盛顿大学化学系，由化学系无机、生物无机和有机金属项目支持，获得职业发展奖，研究从铂(IV)金属中心还原消除反应的能量学和机理。还原消除是有机金属化学中的一个基本反应步骤，在均相催化过程中作为产物的释放步骤发生。本项目的目标是对还原消除的控制因素有一个全面和实际的了解，并开发适用于各种取代基的反应性预测能力。这项工作将推动戈德伯格博士的职业生涯，为在完成这一职业进步奖之后准备一份具有竞争力的NSF研究提案提供基础。例如，涉及铂和钯等金属离子的催化反应在有机合成中很常见，并提供了碳-碳键的形成。这些反应要求有机碎片首先加入金属络合物，然后以某种方式反应，然后释放官能化的分子。释放步骤，即所谓的还原消除，具有根本的重要性，但影响它的因素还没有被很好地理解。将对这一步骤进行系统的研究，以从根本上了解这一过程的机理，并提高预测这些反应结果的能力。

Dr. Karen Goldberg, Department of Chemistry, University of Washington, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division under a Career Advancement Award to study the energetics and mechanisms of reductive elimination reactions from Pt(IV) metal centers. Reductive elimination is a fundamental reaction step in organometallic chemistry occurring as the product release step in homogeneous catalytic processes. The goal of this project is to gain a general and practical understanding of the controlling factors of reductive elimination and to develop predictive capabilities of reactivity applicable to a wide variety of substituents. This work will advance Dr. Goldberg's career by providing a basis for preparing a competitive NSF research proposal subsequent to the completion of this Career Advancement Award. Catalytic reactions involving metal ions such as platinum and palladium are common in organic synthesis and provide for the formation of carbon-carbon bonds, for example. These reactions require that organic fragments first add to the metal complex, then react in some fashion, followed by release of a functionalized molecule. The release step, known as reductive elimination, is of fundamental importance, yet the factors affecting it are not well understood. Systematic studies of this step will be performed to gain a fundamental understanding of the mechanism of this process, and to enhance the ability to predict the outcomes of these reactions.