Asymmetric Catalysis of Carbon-Carbon Bond-Forming Reactions

本研究的重点是镍催化的氢氰化、氢甲酰化和氢乙烯基化等不对称碳-碳键形成反应的研究进展。系统的空间和电子配体调节将导致改进的催化剂的开发，用于生产具有有趣生物学特性的化合物以及聚合物中间体。有了这个新的奖项，合成有机项目将支持俄亥俄州立大学化学系的T.V.RajanBabu博士的研究。RajanBabu教授将专注于开发催化碳-碳键生成反应。将考察氢氰化、氢甲酰化和氢乙烯基化过程。该方法允许催化、立体选择性地将廉价的碳源和氢源并入重要的化学中间体的生产中。

The focus of this research is the development of enantioselective carbon-carbon bond forming reactions involving Ni-catalyzed hydrocyanation, hydroformylation and hydrovinylation. Systematic steric and electronic ligand tuning will lead to the development of improved catalysts for the production of compounds compounds with interesting biological properties as well as polymer intermediates. With this new award, the Synthetic Organic program is supporting the research of Dr. T.V. Rajanbabu of the Department of Chemistry at Ohio State University. Professor RajanBabu will focus his work on developing catalytic carbon-carbon bond making reactions. Hydrocyanation, hydroformylation and hydrvinylation processes will be examined. The methodology allows for the catalytic, stereoselective incorporation of inexpensive carbon and hydrogen sources into the production of important chemical intermediates.