The Chemistry of Fungal Antagonism and Defense

本研究的重点是调查定植菌核的真菌和支寄生真菌。从黄曲霉菌落中分离出的抗真菌药物尤其有可能对曲霉这种重要的条件致病菌和真菌毒素产生者产生作用。研究真菌定植于菌核曲霉作为抑制真菌宿主生长的新型代谢物的来源被认为是前所未有的。有了这个更新奖，合成有机项目支持了爱荷华大学化学系的James B. Gloer博士的研究。格洛尔博士与。美国农业部的Donald T. Wicklow和Patrick F. Dowd将把他的工作重点放在研究真菌对菌核和基质等长寿真菌体的入侵上。这个过程可能经常涉及抗生素，因此，硬化菌群作为抗真菌剂的潜在来源是有用的。

The focus of this research is the investigation of fungicolous and mycoparasitic fungi that colonize sclerotia. Antifungal agents isolated from colonists of Aspergillus flavus are especially likely to exert effects on Aspergillus, an important opportunistic pathogen and mycotoxin producer. Studies of fungi that colonize Aspergillus sclerotia as sources of novel metabolites that inhibit the growth of the fungal host are thought to be unprecedented. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. James B. Gloer of the Department of Chemistry at the University of Iowa. Dr. Gloer, in collaboration with Drs. Donald T. Wicklow and Patrick F. Dowd of the U.S. Department of Agriculture, will focus his work on investigating the fungal invasion of long-lived fungal bodies such as sclerotia and stromata. This process may frequently involve antibiosis and, therefore sclerotial colonists are potentially useful as a source of antifungal agents.