U.S.- U.K. Cooperative Research: Molecular Modeling of Fundamental Mechanisms Governing Protein-Surface Adsorption

这个为期一年的奖项支持美英在生物材料工程方面的合作研究 在克莱姆森大学的罗伯特·拉图尔和帝国理工学院的拉里·亨奇之间， 英国伦敦。 本研究的目的是探讨模型蛋白质在表面的吸附行为. 研究人员将研究 在蛋白质结构的三个基本水平上控制蛋白质吸附：初级（氨基 酸序列），二级（分子链在螺旋、片层中的构型， 环）和三级（二级结构到实际蛋白质结构中的组织）。 在将生物材料植入体内后，蛋白质迅速吸附到生物材料上。 植入材料的表面。 生物反应和身体对植入物的反应 材料通过对该吸附蛋白质层的细胞反应来控制。 这个项目 将促进我们对蛋白质吸附控制机制的理解， 吸附的蛋白质构象，并有助于实现长期目标的设计 植入物表面以控制生物反应。 它利用了英国的专业知识 在帝国理工学院和跨学科的生物材料和蛋白质测序 伦敦大学生物医学材料研究中心。

This one-year award supports US-UK cooperative research on engineering of biomaterials between Robert Latour of Clemson University and Larry Hench of Imperial College, London, United Kingdom. The objective of the research is to investigate model protein- surface adsorption behavior. The investigators will study the fundamental mechanisms governing protein adsorption at the three basic levels of protein structure: primary (amino acid sequence), secondary (configuration of molecular chains in helices, sheets, and loops), and tertiary (organization of secondary structures into the actual protein structure). Following the implantation of a biomaterial into the body, proteins rapidly adsorb onto the implant material's surface. Biologic response and the body's reaction to the implanted material are controlled by cellular reactions to this adsorbed protein layer. This project will advance our understanding of the mechanism controlling protein adsorption and adsorbed protein conformation and contribute toward the long-range goal of designing implant surfaces for controlled biologic response. It takes advantage of British expertise in biomaterials and protein sequencing at Imperial College and at the Interdisciplinary Research Center in Biomedical Materials at the University of London.