Differential Expression of Somatostatin Genes in Rainbow Trout

9723058谢里丹 生长抑素是一个相对多样化的肽激素家族，已知其影响广泛的生物过程，包括生长、发育和代谢。 尽管这组激素意义重大，但人们对它们的进化或控制编码它们的基因的机制知之甚少。 在这个项目中，PI将使用一个简单的模型系统，虹鳟鱼，来研究生长抑素基因表达的基本方面。 他将首次对生长抑素的多基因起源进行明确的分析。 他将描述生长抑素替代形式的表达，并研究生长抑素基因表达如何受各种环境和内源性（即，其它激素如胰岛素）因子。 虽然这项研究涉及具体的鱼类，它将提供重要的新的见解生长抑素基因家族的进化，并产生新的信息与董事会相关的生长抑素介导的控制生长，发育和代谢的理解。

9723058 Sheridan Somatostatins are a relatively diverse family of peptide hormones known to affect a wide array of biological processes, including growth, development, and metabolism. Despite the significance of the group of hormones, little is known about their evolution or about the mechanisms which control the genes that encode them. With this project, the PI will use a simple model system, rainbow trout, to examine fundamental aspects of somatostatin gene expression. He will provide for the first time a definitive analysis of the polygenic origin of somatostatins. He will characterize the expression of alternate forms of somatostatins and investigate how somatostatin gene expression is controlled by various environmental and endogenous (i.e., other hormones such as insulin) factors. While this research pertains specifically to fish, it will provide important new insight into the evolution of the somatostatin gene family and yield novel information with board relevance to the understanding of somatostatin-mediated control of growth, development, and metabolism.