Regulatory Mechanisms of Metabolic Signaling in Plants

9723610 Sheen提出的工作扩展了糖如何影响植物基因表达并因此控制植物发育的分析。营养物质是控制所有生物生理、代谢、细胞周期、发育和基因表达的中枢调控信号。在植物中，已经证明糖控制着许多过程，其中最重要的是通过改变基因表达和导致基因表达的信号传导来调节光合作用。在提议的工作中，糖反应将被定义为通过己糖激酶作为糖传感器介导。包括对己糖激酶的作用机制和信号传递方式的分析。此外，还将研究糖信号通路与其他信号通路之间的串扰。这项工作包括使用对葡萄糖不敏感的拟南芥突变体作为主要成分。通过这项工作获得的信息将提高我们为生物技术目的操纵植物基因的能力。

9723610 Sheen The proposed work extends the analysis of how sugars influence gene expression in plants and hence control plant development. Nutrients are central regulatory signals controlling physiology, metabolism, cell cycle, development, and gene expression in all organisms. In plants, it has been shown that sugars control a number of processes, with a most significant effect on the regulation of photosynthesis through changes in gene expression and signaling leading to gene expression. In the proposed work, sugar responses will be defined which are mediated through hexokinase as a sugar sensor. Included is an analysis of the mechanism through which hexokinase functions and how the signal is transmitted. In addition, cross-talk between the sugar signaling pathway and other signaling pathways will be studied. The work includes the use of Arabidopsis mutants which are insensitive to glucose as a major component. The information gained through this work will enhance our ability for manipulating plants genetically for biotechnological purposes.