Interactive Insect Neuroanatomy Databases for the World Wide Web

该项目将继续开发果蝇中枢神经系统的交互式数据库“Flybrain”，并描述两个级别数据库建设的具体目标。在深层次的基础设施层面（第一级），该项目的具体目标包括提高数据集成和传输的自动化程度；交互式观看和虚拟解剖程序的优化创建显示生理记录的程序；并设计和实现了一个基于概念的搜索引擎。第二阶段的具体目标侧重于增加果蝇胸腹中枢神经系统的第二个核心Arias和并行数据库的实现，两个致力于神经生物学重要昆虫类群的大脑，另一个侧重于节肢动物大脑的进化。这些发展将为后生动物门的大脑和神经系统的组织提供局部的和急需的详细的图形数据，有利于广泛的国际神经科学家和进化生物学家，以及数据库管理和三维数据操作的新工具。在万维网上实施专业管理的神经科学数据库，提供了对中枢神经系统结构和功能的图形数据的即时和极其有效的访问，这些数据与现代研究特别相关。这些数据库的范围从人类大脑的交互式地图集，到斑马鱼、海芋、线虫和果蝇的神经系统数据库（本项目）。美国、德国和日本的三个镜像站点合作设计和实施了该项目，该项目在美国国家科学基金会资助的前16个月取得了意想不到的快速进展。在第一个筹资阶段，在数据库发展的两个层次上取得了重大进展：1)设计和实现一个稳定的框架和强大的机制，以最少的维护来获取、组织、管理、搜索和镜像大量的图像数据；2)安装全面的、带注释的、可搜索的野生型果蝇脑地图集，并与相关数据（如重建的单个神经元、通路和示意图）以及其他昆虫的同源结构相连接。实现了从高度关联的数据模块网络中检索信息的新方法。新颖的图形表示揭示了查看和操作二维和三维结构的新方法。

This project will continue the development of "Flybrain," an interactive database of the central nervous system of Drosophila and describes specific aims for both levels of database construction. At the deep, infrastructural level (level one), the specific aims of the project include increased automation of data integration and transfer; optimization of interactive viewing and virtual dissection programs; creation of programs to display physiological records; and design and implementation of a concept-based search engine. Level two specific aims focus on the addition of a second core Arias of the thoracic and abdominal central nervous system of Drosophila and the implementation of parallel databases, two devoted to the brains of neurobiologically important insect groups, the other focusing on the evolution of arthropod brains. These developments will provide topical and much needed access to detailed graphical data on the organization of brains and nervous systems of the dominant metazoan Phylum, to the benefit of a wide international community of neuroscientists and evolutionary biologists, as well as new tools for database management and manipulation of three-dimensional data. The implementation of professionally managed neuroscience databases on the World Wide Web provides immediate and extremely efficient access to graphic data on the structure and function of central nervous systems that are particularly relevant to modern research. These databases range from interactive atlases of human brains, through databases on the nervous systems of zebra fish, Aplysia, nematodes, and fruit flies (this project). Three mirror sites in the United States, Germany, and Japan have collaborated in the design and implementation of the project which has made unexpectedly rapid progress in the first 16 months of its National Science Foundation funding. Major advances were achieved in the first funding phase at two levels of database development: 1) the design and implementation of a stable framework and robust mechanisms to acquire, organize, manage, search, and mirror large amounts of image data with minimum maintenance and 2) the installation of comprehensive, annotated searchable atlases of wild- type Drosophila brain with links to allied data such as reconstructed single neurons, pathways, and schematics, as well as homologous structures of other insects. New methods have been implemented for retrieving information from a highly linked network of data modules. Novel graphical representations reveal new ways to view and manipulate two- and three-dimensional structure.