SGER: Using Split-Brains to Determine the Role of the Mushroom Body Lobes in Learning and Memory
SGER:利用裂脑确定蘑菇体叶在学习和记忆中的作用
基本信息
- 批准号:0411958
- 负责人:
- 金额:$ 17.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-06-01 至 2006-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Animals (including man) require the hippocampus for remembering places. The present exploratory research project will use novel split-brain strategies to investigate a region of the insect brain called the mushroom body (MB) - a functional analogue of the mammalian hippocampus. Previous research by the Principle Investigator' (PI) has shown that neuronal organization in the MBs is like that of the hippocampus and that the MBs are required for remembering places. The planned research, which is based on extensive information on structural, functional, and developmental attributes of MBs, speaks against orthodox opinion that these brain centers are olfactory analyzers storing olfactory data. Comparisons across species by the PI show that MBs process many types of sensations, as does the hippocampus. MBs will be used as models of the hippocampus to investigate changes that occur in neurons during the learning of a spatial task. The research is unique in that it compares the left and right MBs in a large insect species whose brain can be split before the experiment. Experiments test only one side of the brain using a spatial learning paradigm - associating the position of an image with an odor - perceived by the eye and the antenna of that side. The other "naive" side provides the control. The two sides are used to compare molecular, functional, and structural alterations associated with memory acquisition. This method will allow detection in specific neurons of proteins associated with learning and memory, using fluorescent antibodies. These neurons will be further investigated using recording methods and electron microscopy. Broader impacts of this research: 1) provides paradigmatic shift in our understanding of a learning and memory center; 2) generates data for engineering artificial neuromorphic memory circuits; 3) provides an accessible non-vertebrate model for undergraduate research training.
动物(包括人类)需要海马体来记住地点。目前的探索性研究项目将使用新的裂脑策略来研究昆虫大脑中称为蘑菇体(MB)的区域-哺乳动物海马体的功能类似物。首席研究员(PI)先前的研究表明,MB中的神经元组织与海马体相似,并且MB是记忆位置所必需的。这项计划中的研究是基于对MB的结构、功能和发育属性的广泛信息,反对传统的观点,即这些大脑中心是储存嗅觉数据的嗅觉分析器。PI跨物种的比较表明,MBs处理许多类型的感觉,海马体也是如此。MBs将被用作海马的模型,以研究在空间任务的学习过程中神经元中发生的变化。这项研究的独特之处在于,它比较了一种大型昆虫物种的左右MB,这种昆虫的大脑可以在实验前分裂。实验只测试大脑的一侧,使用空间学习范式-将图像的位置与气味联系起来-由眼睛和那一侧的天线感知。另一个“天真”的方面提供了控制。两侧用于比较与记忆获得相关的分子、功能和结构改变。这种方法将允许使用荧光抗体在特定神经元中检测与学习和记忆相关的蛋白质。这些神经元将进一步研究使用记录方法和电子显微镜。这项研究的更广泛的影响:1)在我们对学习和记忆中心的理解中提供了范式转变; 2)为工程人工神经形态记忆电路生成数据; 3)为本科研究培训提供了一个可访问的非脊椎动物模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicholas Strausfeld其他文献
Brain Structure Resolves the Segmental Affinity of Anomalocaridid Appendages
- DOI:
doi:10.1038/nature13486 - 发表时间:
2014 - 期刊:
- 影响因子:
- 作者:
Peiyun cong;Xiaoya Ma;Xianguang Hou;Gregory Edgecombe;Nicholas Strausfeld - 通讯作者:
Nicholas Strausfeld
Nicholas Strausfeld的其他文献
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{{ truncateString('Nicholas Strausfeld', 18)}}的其他基金
Collaborative Research: Origin and Evolutionary Divergence of the Pancrustacean Brain
合作研究:泛甲壳动物大脑的起源和进化分歧
- 批准号:
1754798 - 财政年份:2018
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
2005 Neuroethology Gordon Research Conferences
2005 年神经行为学戈登研究会议
- 批准号:
0451541 - 财政年份:2005
- 资助金额:
$ 17.24万 - 项目类别:
Standard Grant
Structure and Function of the Insect Mushroom Body in Sensory and Motor Integration
昆虫蘑菇体在感觉和运动整合中的结构和功能
- 批准号:
9726957 - 财政年份:1998
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
Interactive Insect Neuroanatomy Databases for the World Wide Web
万维网交互式昆虫神经解剖学数据库
- 批准号:
9723657 - 财政年份:1997
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
"FLYBRAIN," The First in a Federation of Databases for Insect Neurobiology
“FLYBRAIN”,昆虫神经生物学数据库联盟中的第一个
- 批准号:
9507217 - 财政年份:1995
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
SGER: Neural Systems and Neurogenetic Analysis of Memory Centers
SGER:记忆中心的神经系统和神经遗传学分析
- 批准号:
9316729 - 财政年份:1993
- 资助金额:
$ 17.24万 - 项目类别:
Standard Grant
Synaptic Organization in a Simple Olfactory System
简单嗅觉系统中的突触组织
- 批准号:
9011012 - 财政年份:1991
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
Acquisition of a Computer-Based System for Research on Neuronal Processes
获取用于神经元过程研究的计算机系统
- 批准号:
8716063 - 财政年份:1988
- 资助金额:
$ 17.24万 - 项目类别:
Standard Grant
Neural Circuitry for Polarized-Light Perception
偏振光感知的神经电路
- 批准号:
8719315 - 财政年份:1988
- 资助金额:
$ 17.24万 - 项目类别:
Continuing Grant
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