Development of Instrumentation for the Study of Atomic-Scale Biological Structure by Magnetic Resonance Force Microscopy

拟议的目标是开发一种新的仪器，它将能够无损地、原位、三维地、以埃尺度分辨率成像人类生物分子结构。实现这一目标的技术手段被称为磁共振力显微镜(MRFM)。这种新的仪器技术于1991年由提出者13、14、17首次描述。它结合了扫描探针力显微镜的埃尺度空间分辨率和医学磁共振成像的三维成像能力。

The proposed objective is to develop a new instrument which will be able to image the structure of human biological molecules nondestructively, in situ, in three dimensions, with Angstrom-scale resolution. The technical means by which it is proposed to achieve this goal is called magnetic resonance force microscopy (MRFM). This new instrumentation technology was first described in 1991 by the proposers 13, 14, 17 . It combines the Angstrom-scale spatial resolution of scanning probe force microscopy with the three-dimensional imaging capability of medical magnetic resonance imaging.