Integration of Multinuclear FT-NMR into the Chemistry Curriculum

傅立叶变换核磁共振(FT-核磁共振)光谱学是一种强大的、最先进的分析方法，通常用于工业和研究生院。该项目将现代FT-核磁共振概念更牢固地融入化学课程中。将过时的连续波60-MHz仪器升级为FT系统，可以全面实施该项目。这一升级极大地提高了磁体的效用，而不会引入与超导核磁共振磁体相关的高昂维护和购买成本。升级后的系统提供了(1)早在大二就提供实际核磁共振体验，(2)引入13C核磁共振波谱，(3)进行新的实验室实验(例如，活性中间体的动力学和表征实验)，(4)研究高级核磁共振主题(如FID收集、二维谱、弛豫时间和信号平均)以及(5)执行许多其他新应用的能力。五门以实验室为基础的化学课程的具体改进从大二年级的有机化学开始，一直持续到高级课程。学生毕业时拥有丰富的FT-核磁共振仪器的第一手经验，对核磁共振背后的原理有透彻的了解，并对光谱解释有信心。一个全面的评估计划已经形成，它依赖于对学生在实验室报告、课程考试和国家标准化核磁共振相关测试题上的表现的评估。*

Fourier-transform nuclear magnetic resonance (FT-NMR) spectroscopy is a powerful, state-of-the-art analytical method used commonly in industrial and graduate school settings. This project integrates modern FT-NMR concepts more firmly into the chemistry curriculum. An upgrade of an outdated, continuous-wave 60-MHz instrument to an FT system allows full implementation of the project. This upgrade dramatically increases the utility of magnets without introducing the high maintenance and purchasing costs associated with a superconducting NMR magnet. The upgraded system provides the capability to (1) provide hands-on NMR experience as early as the sophomore year, (2) introduce 13C NMR spectroscopy, (3) perform new laboratory experiments (e.g., experiments in kinetics and characterization of reactive intermediates), (4) investigate advanced NMR topics (such as FID collection, two-dimensional spectra, relaxation times, and signal-averaging) and (5) perform a host of other new applications. Specific improvements in five laboratory-based chemistry courses begin with sophomore-level organic chemistry and continue through senior-level advanced courses. Students graduate with extensive first-hand experience on an FT-NMR instrument, a thorough knowledge of the principles behind NMR, and confidence in spectral interpretation. A comprehensive evaluation plan has been forged which relies on assessment of student performance on laboratory reports, course exams, and nationally standardized NMR-related test questions. *