RUI: Investigation of the Properties and Reactivities of 1,2-Diazetine Dioxides

RUI：1,2-二氮杂环己烷的性质和反应性研究

• 批准号: 0405034
• 负责人: Gary Breton
• 金额: $ 11.34万
• 依托单位: Berry College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0405034&HistoricalAwards=false
• 关键词: RUI; Investigation; Properties; Reactivities; Diazetine

With the support of the Organic Dynamics Program in the Chemistry Division, Professors Gary W. Breton of Berry College will seek to expand our knowledge of the diazetine dioxides, a very specific class of compounds that was discovered in 1971. They received attention in only a few good papers until the discovery that nitric oxide was of great physiological importance and that diazetine dioxides liberate this simple gas. Professor Breton is proposing a more detailed investigation of their chemistry. Experiments and computations to determine the mechanism of decomposition of 1,2-diazetine dioxides will be carried out. These compounds are potenially interesting precursors to nitric oxide under physiological conditions. Different compounds with varying degrees of strain will be prepared and the rates and thermodynamic parameters for the decomposition will be determined and the products characterized. The mechanism of NO extrusion from diazetine dioxide will be studied in conjunction with the effect of strain energy on the rate of NO loss from the 4-membered heterocycles. The results should be a much better understanding of this reaction. The Organic and Macromolecular Chemistry Program supports Professors Gary W. Breton of Berry College who will undertake a well-designed project that has a strong focus on kinetics and mechanism. The project will provide students with challenges that will present several levels of increasing difficulty. The project is well planned and will likely produce broadly interesting results that will provide for the students involved a sophisticated initiation into modern chemical research. Nitric oxide has important physiological properties, and an ability to tune the production rates from the precursors synthesized could have useful medical implication.

在化学系有机动力学项目的支持下，贝瑞学院的加里·W·布雷东教授将寻求扩大我们对二氮杂二氧化物的知识，这是1971年发现的一类非常特殊的化合物。他们只在几篇优秀的论文中受到关注，直到发现一氧化氮具有极大的生理重要性，二氮杂二氧化物释放出这种简单的气体。布雷顿教授提议对它们的化学成分进行更详细的研究。将进行实验和计算，以确定1，2-二氮杂二氧化物的分解机理。在生理条件下，这些化合物可能是一氧化氮的前体。将制备具有不同应变程度的不同化合物，并将确定分解的速率和热力学参数，并对产物进行表征。我们将结合应变能对四元杂环NO损失率的影响来研究二氧化二氮挤出NO的机理。结果应该会更好地理解这种反应。有机化学和高分子化学计划支持贝瑞学院的加里·W·布雷东教授，他将进行一个设计良好的项目，重点放在动力学和机理上。该项目将为学生提供挑战，这些挑战将呈现出几个不断增加的难度。该项目计划周密，可能会产生广泛有趣的结果，为参与其中的学生提供进入现代化学研究的复杂开端。一氧化氮具有重要的生理特性，从合成的前体中调节产量的能力可能具有有用的医学意义。