Well-Controlled Polymer Structures via Metathesis Polycondensation Chemistry

9806492 Wagener该奖项针对几个特定的研究目标。将设计一系列明确的聚烯烃聚合物，以模拟聚乙烯及其相关共聚物的结晶行为，包括新的茂金属材料。综合的概念已经付诸实践，因此本研究成功的可能性很高。这将通过实现对主干分支的身份和频率的完全控制来完成。本研究的内在内容将是阐述新的均相-非均相复合/加氢化学。明确的醇和酯支化聚合物将被合成作为聚合物底物在一个sialyl Lewis X四糖药物结合研究。这项工作将与Scripps研究所的黄教授合作完成。通过缩合复分解可以合成精确的分段聚合物。分段多相材料只能通过逐步聚合程序，使ADMET反应是这种转化的自然选择。这种合成策略已经被证明，并且将探索用聚醚、聚硅氧烷和聚异丁烯软段制备有用的硬段。定义良好的混合富金属均聚物将被制备成具有不同金属共价固定在同一聚合物链内。虽然已经通过缩合复分解合成了共价结合的含金属聚合物，但具有如此高混合金属含量的聚合物尚不为人所知。这些领域都为培养博士后、博士和本科生的未来提供了重要的机会。与工业界的互动仍然很密切，这项工作产生的信息将促进与一些公司的持续关系。这项研究的社会影响涉及扩大世界上体积最大的商品聚合物和共聚物的用途，如聚乙烯、聚苯乙烯和聚乙烯乙酸酯。* * *

9806492 Wagener This award addresses several specific research goals. A series of well defined polyolefin polymers will be designed to model the crystallization behavior of polyethylene and its related copolymers, including the new metallocene materials. The synthesis concept has already been reduced to practice, so the likelihood of success in this research is high. This will be done by implementing total control over the identity and frequency of branches along the backbone. Inherent in this research will be work to elaborate on new homogeneous-to- heterogeneous metathesis/hydrogenation chemistry. Well- defined alcohol and ester branched polymers will be synthesized to serve as polymeric substrates in a sialyl Lewis X tetrasaccharide drug binding study. This work will be done in collaboration with Prof. Wong of the Scripps Research Institute. Precise segmented polymers will be synthesized by condensation metathesis. Segmented multiphase materials can only be made by step polymerization procedures, making the ADMET reaction a natural choice for this conversion. This synthetic strategy has already been demonstrated, and the preparation of useful hard segments will be explored using polyether, polysiloxane, and polyisobutylene soft segments. Well defined, mixed metal rich homopolymers will be prepared possessing different metals covalently fixed within the same polymer chain. %%% While covalently bound metal containing polymers have already been synthesized via condensation metathesis, polymers with such high mixed metal content polymers are not known. Each of these areas provides significant opportunity for the training of postdoctoral, Ph.D. and undergraduate students for their future. Interaction with industry continues to be strong, and the information generated by this work will foster continuing relations with a number of corporations. The social impact of this research relates to broadening the usefulness of the world's largest volume, commo dity polymers and copolymers such as polyethylene, polystyrene and polyvinylacetate. ***