High Resolution Laser Speckle Strain Gauge for Biomedical Research and Diagnostics

9807497Kirkpatrick本研究的目标是实现一种创新的成像激光散斑应变计，用于生物医学研究和诊断。 这项研究开发和应用这样的应变计越来越困难的生物医学问题，包括非接触评估皮质骨和合成生物材料，由于应力集中的局部微应变变化的评价，和生物软组织的微观力学分析。 本研究的具体假设是：（1）改进的激光散斑应变测量技术可以提供关于生物组织和合成生物材料的力学行为的详细信息，具有比传统测量技术更高的应变分辨率，包括经典的激光散斑干涉方法，（2）局部力学性质的变化可以表现出来，因此成像目的的对比度变化。 使用用于数据收集和分析的改进的成像激光散斑算法，可以定量分析结构不均匀性周围的局部应变场的变化，以及（3）软组织（例如，皮肤、肌腱、动脉）的测量是可能的。

9807497KirkpatrickThe goal of this research is to implement an innovative imaged laser speckle strain gauge for biomedical research and diagnosis. This research develops and applies such a strain gauge to increasingly difficult biomedical issues including the non-contacting evaluation of cortical bone and synthetic biomaterials, the evaluation of local microstrain variations due to stress concentrations, and the micromechanical analysis of soft biological tissues. The specific hypotheses of the research are: (1) improved laser speckle strain measurement technology can provide detailed information on the mechanical behavior of biological tissues and synthetic biomaterials with a greater strain resolution than conventional measurement techniques, including classical laser speckle interferometric methodologies, (2) variation in local mechanical properties can manifest itself so contrast variations for imaging purposes. Using an improved imaged laser speckle algorithm for data collection and analysis, the variations in the local strain fields around structural inhomogeneities can be quantitatively analyzed, and (3) direct strain measurement in soft tissue (e.g., skin, tendons, arteries) is possible using the proposed imaged laser speckle strain gauge.***