U.S.-Germany Cooperative Research: RNA Editing and Cytoplasmic Male Sterility in Sorghum

9815695Pring该奖项支持PI， Daryl Pring和佛罗里达大学的一名研究生与德国波鸿鲁尔大学普通植物系的Frank Kempken合作。本研究的目的是探讨高粱细胞质雄性不育性。PI先前的工作提供了遗传和分子证据，证明细胞核和线粒体之间有缺陷的相互作用导致花粉败育。两个恢复生育能力的基因纠正了这种有害的相互作用——其中一个基因的作用是明确的，而另一个则不清楚。这项研究将融合独特的遗传和分子资源，以确定第二个基因的功能。更一般地说，该项目有可能证明RNA编辑在正常生殖过程中的独特作用，并证明一种新的花粉特异性RNA编辑调节。

9815695PringThis award supports the PI, Daryl Pring and a graduate student from the University of Florida in a collaboration with Frank Kempken of the Department of General Botany at the Ruhr-University in Bochum, Germany. The goal of the research is to explore cytoplasmic male sterility in sorghum. Prior work by the PI has provided genetic and molecular evidence that defective interactions between the nucleus and the mitochondrion result in pollen abortion. Two fertility restoration genes correct this deleterious interaction-the role of one of those genes is clear, but of the other is not. This research will meld unique genetic and molecular resources to identify the function of the second gene. In more general terms, the project has the potential to demonstrate a unique role of RNA editing in normal reproductive processes, and demonstrate a new pollen-specific regulation of RNA editing.