Studies in Aziridine-Allylsilane Cyclizations

伯格迈耶教授的研究探索了烯丙基硅烷和叠氮吡啶分子内反应所引起的环化反应。根据所选择的条件，该反应将产生碳环同丙烯胺或融合的双环吡咯烷。进一步的研究将确定反应中立体选择性的程度，并确定那些可以改变以控制其立体化学的因素。正式的[3+2]环化将被扩展，以提供制备多个多环分子的方法。最后，天然产物的合成将在可能有利于确定合成方法的实用性的地方进行，因为它们是精炼的。通过这个奖项，有机和大分子化学项目支持俄亥俄州立大学Stephen C. Bergmeier教授的研究。伯格迈耶教授研究的化学反应能使单一前体产生不同的分子。各种各样的天然化合物以及合成的药物分子已经被确定，伯格迈耶的化学方法可以提供方便的途径。

Professor Bergmeier's research explores cyclization reactions brought about by the intramolecular reaction of an allylsilane and an aziridine. The reaction will yield either a carbocyclic homoallylic amine or a fused bicyclic pyrrolidine, depending on the conditions that are selected. Further study will determine the extent of stereoselectivity in the reaction and identify those factors that can be altered to control its stereochemistry. The formal [3+2] cyclization will be expanded upon to provide the means of preparing multiple polycyclic molecules. Finally, natural product synthesis will be undertaken where it may be advantageous to establish the utility of the synthetic methods as they are refined.With this award, the Organic and Macromolecular Chemistry Program supports the research of Professor Stephen C. Bergmeier of the Ohio State University. Professor Bergmeier studies chemical reactions that enable the creation of different molecules from a single precursor. A wide variety of naturally occuring compounds as well as synthetic pharmaceutical molecules have been identified for which Bergmeier's chemistry would provide easy access.