U.S.-Korea Cooperative Research: Micropatterned Neural Networks and Microelectrode Arrays

9816376惠勒该奖项提供资金，允许伊利诺伊大学厄巴纳分校电气和计算机工程系的Bruce C.Wheeler博士与首尔国立大学电气工程学院的Sung JunKim博士进行为期24个月的关于微图案化神经网络和微电极阵列的合作研究计划。在这个项目中，伊利诺伊大学的神经细胞构图专业知识与首尔国立大学的微电子制造专业知识相结合。伊利诺伊大学的研究小组已经证明，新的表面处理可以用来在培养中培养微图案神经网络。这项技术的基本要素是能够延缓细胞在背景区域的附着和生长，将胞体限制在所需的位置，并控制轴突延伸以创建定向网络。微平版印刷技术，主要是微接触印刷，将被用来在平面培养表面产生生物分子的图案，以实现对神经元和神经胶质细胞附着和延伸的位置的控制。韩国团队将通过在常规基础上提供无源电极阵列，并追求用于电极设计的新制造技术，极大地加强伊利诺伊州的努力。此外，韩国团队将设计和制造包含有源电子设备的阵列，用于刺激、放大和多路复用。他们的仪器目标是通过将第一级放大器放置在接近低电平信号源的位置来获得更好的信噪比。韩国团队在微电子制造方面拥有强大的能力，并已经制造出用于神经信号放大的设备。在这个项目上的合作将提供一个生物背景，以改进他们的设计，使两个团队受益。两个研究团队的互补专业知识将互惠互利，并将促进这一重要研究领域的知识。合作者在各自的研究领域都是备受推崇的科学家。韩国和美国的研究生将被包括在合作团队中。该项目与美韩合作科学计划的目标相关，该计划旨在通过交流科学信息、想法、技能和技术以及通过在互利问题上的合作来提高美国和韩国科学家和工程师之间的合作水平。韩国的参与得到了韩国科学与工程基金会(KOSEF)的支持。

9816376WheelerThis award provides funds to permit Dr. Bruce C. Wheeler, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Chamoaign, to pursue with Dr. Sung June Kim, School of Electrical Engineering, Seoul National University, for 24 months, a program of cooperative research on micropatterned neural networks and microelectrode arrays. In this project, the neuronal cell patterning expertise at the University of Illinois is coupled with the microelectronics fabrication expertise at Seoul National University. The research team at the University of Illinois has shown that novel surface treatment can be used to grow micropatterned neural networks in culture. Essential elements of the technology are the ability to retard cell attachment and growth from background areas, to confine somata to desired positions, and to control axonal extension so as to create an oriented network. Microlithographic techniques, primarily microcontact printing, will be used to create patterns of biomolecules on planar culture surfaces in order to effect control of position of attachment and extension of neurons and glia. The Korean team will greatly enhance the Illinois efforts by making passive electrode arrays available on a routine basis and pursuing novel fabrication technologies for electrode design. In addition the Korean team will design and fabricate arrays incorporating active electronics for stimulation, amplification, and multiplexing. Their instrumentation goal is to obtain better signal to noise ratio by placing first stage amplifiers nearly in contact with the low level signal source. The Korean team has substantial capabilities for microelectronic fabrication and already has made devices for neural signal amplification. Collaboration on this project will provide a biological context in which to improve their designs, for the benefit of both teams.The complementary expertise of the two research teams will be mutually beneficial and will advance knowledge in this important field of research. The collaborators are highly regarded scientists in their respective fields of research. Korean and American graduate students will be included in the teams of collaborators. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).***