Purchase of Circular Dichroism Spectrometer for Research in Carcinogen-DNA Interactions

这份来自化学研究仪器和设施(CRIF)/初级教师计划的合同将允许北达科他大学化学系购买圆二色（CD）光谱仪。该仪器将主要由初级教员Mahesh Lakshman用于他的研究项目，涉及糖苷的合成和热学性质的研究；以及研究致癌物质与dna相互作用的化学合成。本系亦计划将CD光谱法纳入进阶有机与物理化学实验课程。长期以来，光学活性的测量在有机化学和生物化学的发展中起着重要的作用。圆二色性的研究提供了关于单个分子或离子的电子状态或结构的重要信息。这些技术用于研究分子的绝对构型、反应机理和动力学、不对称或立体定向合成、溶解物质的热力学性质以及许多其他立体化学问题。

This award from the Chemistry Research Instrumentation and Facilities (CRIF)/Junior Faculty Program will allow the Department of Chemistry at the University of North Dakota to purchase a circular dichroism (CD) spectrometer. This instrument will be used primarily by Mahesh Lakshman, a junior faculty member, for his research program involving the synthesis and study of chiroptical properties of glycosides; and chemical synthesis for the study of carcinogen-DNA interactions. The department also plans to incorporate CD spectrometry into the advanced organic and physical chemistry laboratory courses. Measurements of optical activity have long played an essential role in the development of organic chemistry and biochemistry. The study of circular dichroism provides important information about the electronic states or structures of individual molecules or ions. These techniques are used when studying absolute configurations of molecules, reaction mechanisms and kinetics, asymmetric or stereospecific syntheses, thermodynamic properties of dissolved species, and many other stereochemical problems.