CONFERENCE: 1999 CSHL Meeting on Tyrosine Phosphorylation and Cell Signalling

蛋白酪氨酸激酶及其伴侣磷酸酶是许多细胞信号通路的关键调控元件，这些信号通路控制着细胞分裂、细胞间通讯和细胞分化等基本和必要的功能。这些途径的控制在免疫反应中淋巴细胞的激活和抑制、涉及相互作用的细胞类型的发育途径的整合以及阻止肿瘤细胞生长等重要过程中也是至关重要的。这次会议是1995年开始的关于这些专题的年度系列会议的延续。今年会议的目的是(1)研究与其特定调控环境相关的这些激酶和磷酸酶的结构、功能和调控，(2)概述最近取得重大进展的特定领域，包括与磷脂依赖信号和新的遗传方法的相互作用的研究，以及(3)通过将年轻科学家纳入该计划来鼓励他们的发展。会议的安排包括两次受邀的主旨演讲，然后是专题会议，所有发言将从会议参与者的摘要中选出。将不会有预先确定的发言者名单。会议主席将与会议组织者分担选择发言者的责任，并将概述每个领域的当前状况。所有参与者都将有机会在海报会议上展示调查结果。会议摘要将由冷泉港出版社面向普通科学界出版。组织者鼓励学生、年轻研究人员、妇女和代表不足的少数族裔参加。

Protein tyrosine kinases and their partner phosphatases are key regulatory elements of many cell signaling pathways that control such basic and essential functions as cell division, cell-cell communication, and cell differentiation. Control within these pathways is also critical in such important processes as activation and inhibition of lymphocytes in immune responses, integration of developmental pathways involving interacting cell types, and prevention of neoplastic cell growth. This conference is a continuation of an annual series of conferences on these topics which began in 1995. The aims of this year's meeting are (1) to examine the structure, function and regulation of these kinases and phosphatases as related to their specific regulatory context, (2) to provide overviews of specific areas in which recent significant advances have been made, including studies on the cross-talk with phosholipid-dependent signaling and new genetic approaches, and (3) to encourage the development of young scientists, including women and minorities, by their inclusion in the program. The organization of the meeting consists of two invited keynote addresses followed by topical sessions in which all presentations will be chosen from the abstracts of meeting participants. There will be no predetermined list of speakers. Session chairs will share the responsibility of choosing speakers with the meeting organizers and will give overviews of the current status of each field. All participants will have an opportunity to present findings in poster sessions. Meeting abstracts will be published by Cold Spring Harbor Press for the general scientific community. The organizers encourage the participation of students, young investigators, women, and under-represented minorities.