POWRE: Evolution of Plant Resistance Genes

9870516 5月这项研究将分析分子重排在茄科植物中一个复杂的病毒抗性基因N位点上产生新等位基因的重要性。对重排的进化重要性的分析将解决如何组织植物基因组结构以提供对微生物病原体的持续抗性的问题。在这些分析中，调查者将利用对改变的抗性等位基因的强大功能选择来恢复茄科物种中N的重排。将这些结果与茄科相关物种中N基因座的结构进行比较，将有助于评估重排在产生新的N基因和等位基因方面的进化重要性。了解寄主植物及其相关微生物的分子进化相互作用对于开发低生态影响的可持续农业系统至关重要，并可以确定植物保护的新方法。

9870516 May This research will analyze the importance of molecular rearrangements in generating new alleles at the N locus, a complex viral resistance locus in the Solanaceae. Analysis of the evolutionary importance of rearrangements will address the question of how the genomic architecture of plants might be organized to provide continued resistance to microbial pathogens. In these analyses, the investigator will take advantage of a strong functional selection for altered resistance alleles to recover rearrangements at N in Solanaceae species. Comparing these results to the structure of the N locus in related species within the Solanaceae will allow assessment of the evolutionary importance of rearrangements in generating new N genes and alleles. Understanding the molecular evolutionary interactions of host plants and their associated microorganisms is essential to developing sustainable agricultural systems with low ecological impact and can define novel approaches to plant protection.