Carboxylate Salt Receptors

该项目探讨了羧酸盐受体的各个方面，包括对特定芳香酸盐的膜选择性，膜扩散的NMR研究，以及细菌膜特有的二肽受体。 盐特异性液膜将允许用于从其烃原料中分离羧酸产物的低能量、连续且环境友好的方法。 脉冲场梯度核磁共振表明，膜扩散常数并不总是独立的身份的金属阳离子。 天然羧基离子载体将进行研究，以确定这种影响的程度和性质。 组合方法将允许识别与二肽的C-末端选择性结合的分子，通过延伸，将为万古霉素等重要抗生素提供模拟物。有了这个奖项，有机和大分子化学计划继续支持布拉德利D教授的研究项目。圣母大学的史密斯。 史密斯教授探讨了膜结合分子识别特定羧酸并与之结合的能力。 这种现象是重要的，因为潜在的工业应用的选择性分离的特定物质的优先运输通过一个膜。 此外，将获得对细菌膜和某些抗生素分子性质的更好理解。

This project explores various aspects of carboxylate salt receptors, including membranes selective for specific aromatic acid salts, NMR studies of membrane diffusion, and receptors for dipeptides peculiar to bacterial membranes. Salt-specific liquid membranes would allow for a low-energy, continuous, and environmentally benign method for separation of carboxylic acid products from their hydrocarbon feedstocks. Pulsed field-gradient NMR has shown that membrane diffusion constant is not always independent of the identity of the metal cation. Natural carboxylic ionophores will be studied to determine the extent and nature of this effect. Combinatorial methods will permit the identification of molecules that bind selective with the C-terminus of dipeptides that, by extension, will provide mimics for such important antibiotics as vancomycin.With this Award, the Organic and Macromolecular Chemistry Program continues support for the research project of Professor Bradley D. Smith of The University of Notre Dame. Professor Smith explores the ability of membrane-bound molecules to identify specific carboxylic acids and to bind to them. This phenomenon is important because of potential industrial applications for the selective isolation of specific substances by their preferential transport across a membrane. Additionally, a better understanding of bacterial membranes and the nature of certain antibiotic molecules will be gained.