Syntheses and Chemistry of Chlorophylls and Derivatives

在有机合成项目的支持下，加州大学戴维斯分校化学系的凯文·史密斯教授正在研究叶绿素及相关化合物的合成和化学。史密斯教授的研究主要集中在非平面卟啉的合成和结构、calixareno卟啉、光动力治疗的敏化剂、构象锁定的光敏色素发色团、芳香融合的卟啉系统和卟啉-茂金属系统，以及卟啉和酞菁基系统的Diels-Alder化学。卟啉和叶绿素是生命过程中重要的催化剂和媒介，增加对它们的化学和生物学的理解仍然是一个重要的目标。叶绿素是光合作用的催化剂，而卟啉及其金属配合物，除其他外，作为叶绿素的仿生物和作为治疗肿瘤的潜在光化学增敏剂。加州大学戴维斯分校化学系的凯文·史密斯教授，因其对多种卟啉、叶绿素和相关化合物的合成、结构和反应性的研究而受到有机合成计划的支持。通过这些研究，史密斯教授不仅解决了仿生学和光敏化的具体问题，而且还开发了进一步开发这些重要的天然（或自然启发）产品所需的基本合成工具。

With the support of the Organic Synthesis Program, Professor Kevin Smith, of the Department of Chemistry at the University of California at Davis, is studying the synthesis and chemistry of chlorophylls and related compounds. Professor Smith's studies are focused on the synthesis and structure of nonplanar porphyrins, calixarenoporphyrins, sensitizers for photodynamic therapy, conformationally-locked phytochrome chromophores, aromatic-fused porphyrin systems, and porphyrin-metallocene systems, as well as on the Diels-Alder chemistry of porphyrin and phthalocyanine-based systems.Porphyrins and chlorophylls are vital catalysts and agents in life processes, and an increased understanding of their chemistry and biology remains an important objective. Chlorophylls are the catalysts in photosynthesis, while porphyrins and their metal complexes serve, inter alia, as biomimics of chlorophylls and as potential photochemical sensitizers for treatment of tumors. Professor Kevin Smith, of the Department of Chemistry at the University of California at Davis, is supported by the Organic Synthesis Program for his studies of the synthesis, structure, and reactivity of a wide variety of porphyrin, chlorophyll, and related compounds. Through these studies, Professor Smith is not only addressing the specific issues of biomimicry and photosensitization, but also is developing the fundamental synthetic tools required for the further development of these important natural (or naturally-inspired) products.