U.S.-Australia Cooperative Research: Regulation of the Ryanodine-Receptor by the DHP-Receptor

该奖项支持明尼苏达大学Esther Gallant博士和澳大利亚国立大学Angela Dulhunty博士在“dhp受体对Ryanodine-Receptor的调控”方面的合作。这是一个研究肌肉细胞中ryanodine受体调控的项目。该提案的具体目标是使用在人工膜中重组的受体来确定最佳通道功能所需的共蛋白和配体的浓度，并研究在这些条件下由二氢吡啶受体的肽激活的通道功能。

9907646GallantThis award supports collaboration between Dr. Esther Gallant, University of Minnesota, and Dr. Angela Dulhunty, Australian National University, on "Regulation of Ryanodine-Receptor by the DHP-Receptor". This is a project to study the regulation of the ryanodine receptor of muscle cells. Specific goals of the proposal are to use receptors reconstituted in artificial membranes to determine concentrations of co-proteins and ligands necessary for optimal channel function and to study channel function under these conditions when activated by peptides from the dihydropyridine receptor..