US-Turkey Cooperative Research: Coil-to-Globule Transitions in Polymer Solutions

9911091 Karasz描述：该项目支持马萨诸塞州阿默斯特大学聚合物科学与工程系Frank Karasz教授和土耳其盖布泽马尔马拉研究中心（MRC）基础科学研究所所长Bahattin Baysal博士的合作项目。这两位科学家建议将他们的研究扩展到聚合物-溶剂系统。 他们打算将研究扩展到更高极性的体系，特别是聚（N-异丙基丙烯酰胺），聚（N-正丙基丙烯酰胺）及其在稀水溶液中的无规共聚物。 此外，他们将研究在选定的无规共聚物-溶剂系统中的卷曲塌陷，前提是这构成了简单均聚物和高度复杂蛋白质情况之间的中间步骤。 他们建议使用动态光散射技术详细研究极性大分子在近θ条件下的线圈塌陷。 这项研究的应用是在有关的聚合物行为的情况下的生物structures.Scope：该提案解决了一个重要的领域，即崩溃过渡的大分子从线圈的紧凑的球状状态。 这种对聚合物卷曲在不良溶剂中的坍塌的研究与某些生物过程密切相关，包括蛋白质折叠和DNA包装。这位美国研究人员是聚合物科学领域的知名研究领导者。这位土耳其科学家是一位国际知名的聚合物化学家，他领导着土耳其主要政府研究机构MRC的一个强大的科学家小组，MRC位于伊斯坦布尔附近。 该项目符合国际方案司（INT）支持互利研究的使命。 该项目由INT和材料研究部支持。

9911091Karasz Description: This project supports a cooperative project by the Professor Frank Karasz, Department of Polymer Science and Engineering, University of Massachusetts at Amherst and Dr. Bahattin Baysal, Director, Research Institute of Basic Sciences at the Marmara Research Center (MRC) in Gebze, Turkey. The two scientists propose to extend their research on polymer-solvent systems. They intend to extend the studies to more highly polar systems, in particular to poly(N-isopropyl acrylamide), poly(N-n-propylacrylamide) and their random copolymers in dilute aqueous solution. In addition they will study coil collapse in a selected random copolymer-solvent system, on the premise that this constitutes an intermediate step between the simple homopolymer and the highly complex protein cases. They suggest using dynamic light scattering techniques for detailed studies of coil collapse in near theta conditions for polar macromolecules. The application of this research is in relating the polymeric behavior to cases of biological structures.Scope: The proposal addresses an important area, that of collapse transition of macromolecules from the coil to the compact globular state. This research on polymer coil collapse in poor solvents is intimately related to certain biological processes, including protein folding and DNA packing. The US investigator is a well-known research leader in polymer science. The Turkish scientist is an internationally known polymer chemist who leads a strong group of scientists at Turkey's major governmental research establishment, the MRC, near Istanbul. This project fits the mission of the Division of International Programs (INT) for support of mutually beneficial research. The project is supported by INT and the Division of Materials Research.