Design of Targeted Toxins with Enhanced Membrane Translocation

本项目的目的是定量分析受体介导的细胞毒素转运动力学，以开发一种具有高度选择性的靶向给药治疗疾病的方法。该项目概述了一项定量评估靶向分子对毒素运输到动物细胞内部的影响的计划。这个项目延续了使用多肽来改变免疫毒素的细胞处理的总主题。具体地说，利用内吞作用与细胞内膜破坏多肽一起进口药物，被认为是一种增加治疗药物对其细胞内靶点(例如核糖体)的输送的手段。

The objective of this project is the quantitative analysis of receptor-mediated cytotoxin trafficking dynamics in order to develop a highly selective method for treating diseases by targeted drug delivery. The project outlines a plan for quantitatively assessing the effect of targeting molecules on the transport of toxins to the interior of animal cells. This project continues the general theme of using peptides to modify cellular processing of immunotoxins. Specifically, using endocytosis to import drugs in tandem with endosomal membrane-disrupting peptides is proposed as a means for augmenting the delivery of a therapeutic to its intracellular target (e.g. ribosomes).