SBIR Phase II: Optical Diffusion Tomography in Frequency Domain by the Elliptic Systems Method

这个小企业创新研究第二阶段项目建立在第一阶段拨款的概念基础上，开发一种可用于乳腺癌筛查或诊断的光学乳房x光摄影设备的临床原型。发展光学乳房x光造影设备的主要技术障碍是需要在散射光存在下快速准确的成像算法，以及开发能够以安全及时的方式收集足够光子以形成准确图像的测量技术。第一阶段演示了算法和硬件新方法的技术可行性。该项目的软件目标包括测试一种计算夹杂物吸收系数的方法，修改软件以直接定位夹杂物而无需转换，以及开发三维和GUI界面。硬件目标包括开发一种临床原型，该原型将安全且适合于对人类受试者进行成像，并根据实验数据校准和测试硬件/软件设备。

This Small Business Innovation Research Phase II project builds upon the concepts developed in the Phase I grant to develop a clinical prototype of an optical mammography device that could be used for breast cancer screening or diagnosis. The major technical obstacles to the development of an optical mammography device have been the need for imaging algorithms that are fast and accurate in the presence of scattered light, and fordeveloping measurement techniques that can collect enough photons in a safe and timely way to develop an accurate image. Phase I demonstrated the technical feasibility of a new approach to the algorithms and hardware. The software objectives of this project involve testing an approach to compute inclusion absorption coefficients, modifying the software to directly locate inclusions without transformation and developing a 3-D and GUI interface. Hardware objectives include developing a clinical prototype that would be safe and appropriate for imaging human subjects and calibrating and testing the hardware/software device on experimental data.