NANOSCALE: An Electronic Gain Cell for Monitoring Charge on Molecular Chains

该提案概述了一种用于大分子链上电荷的静电耦合的方法（例如，核酸和多肽）到电子从栅极金属氧化物半导体场效应晶体管（MOSFET）的源极到漏极的流动，并提出探索和证明该方法通过使用晶体管的增益来确定尺寸、电荷和基极组成的能力。提出了两种不同的几何结构：第一种是前流体流动通道器件，其流动通道的横截面为5-20 nm × 1-10 nm，并置于硅上制成的晶体管的栅极和电子通道之间，允许单电子灵敏度，并在伸长时与直径小于10 nm的分子粒子一起工作。第二，背流体流动通道装置，具有横截面为5 nm（和更大）乘40-400 nm的流动通道，并且放置在薄硅通道晶体管下方，允许对尺寸更大的分子进行灵敏测量。

9986535Sandip TiwariThis proposal outlines a method for electrostatic coupling of the charge on macro-molecular chains (e.g., nucleic acids and polypeptides) to the flow of electrons from source to drain of a gated metal-oxide-semiconductor field-effect transistor (MOSFET) and proposes to explore and demonstrate the method's ability to determine size, charge, and base composition by using the gain of the transistor. Two different geometries are proposed: the first, a front fluid flow channel device, with a flow channel 5-20 nm by 1-10 nm in cross-section and placed in between the gate and the electron channel of the transistor made on silicon, allows single-electron sensitivity and operates with molecular spe-cies that are sub-10 nm in diameter when elongated. The second, a back fluid flow channel device, with a flow chan-nelthat is 5 nm (and larger) by 40-400 nm in cross-section and placed underneath a thin-silicon channel transistor, allows for sensitive measurements for molecules that are larger in size.