NANOSCALE: Engineered Alpha Helices for Pore Transport Regulation

摘要提案号：es -9986538提案类型：响应NSF 99-109，纳米尺度下生物系统的探索性研究，负责人：Peter K. kilpatrick，隶属机构：北卡罗莱纳州立大学，纳米尺度：用于孔运输调节的工程α螺旋，该探索性项目研究含有螺旋聚合物的纳米结构嵌段共聚物膜的制备和功效。目的是模拟生物系统，以实现生物溶质的高运输选择性。形成不同疏水性程度螺旋的各种聚合物微结构将被合成并组装在平面磷脂单层和囊泡膜中。各种结构的能力将被探测，以确定他们的能力，控制溶质运输通过膜根据疏水性的螺旋外围和由此产生的孔径大小。运输测量是用放射性和荧光溶质进行的。

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured block-copolymer membranes containing helical polymers. The objective is to mimic biological systems in order to achieve high transport selectivity for biological solutes.Various polymeric microstuctures that form helices with varying degrees of hydrophobicity will be synthesized and assembled in planar phospholipid monolayers and in vesicular membranes. The ability of the various structures will be probed to determine their ability to control solute transport through the membranes according the hydrophobicity of the helix periphery and the resulting pore sizes. Transport measurements are being done with radioactive and fluorescent solutes.