SBIR Phase I: Latent-Reactive Surface Modification Reagents for Biofilm Control

这个小企业创新研究（SBIR）第一阶段项目旨在开发新的试剂，用于在与塑料相容的温度下将水溶性杀微生物聚合物和表面活性剂粘合到各种不透明管道材料的管腔表面。已经开发出具有运输水和含水混合物所需的散装物理性质的材料；然而，在牙科、制药、食品加工和海洋运输行业中，湿表面生物膜的发展一直是一个严重的问题。水线的表面改性可以减少生物膜的形成，同时保持管道所需的体积特性。光化学在射频等离子体或紫外光引发的基基表面修饰增强医疗设备的表面特性方面已被证明是商业上成功的。然而，这些能源不能有效地改变“不透明”管道的内表面，如牙科单位使用的水管和制药厂的塑料管道。该项目旨在开发可通过穿透这些“不透明”设备的外部能源激活的潜在反应性自由基发生器。这种创新的自由基发生器计划激活方法有望促进与许多“惰性”表面的耦合，这些表面不能被外部光或等离子体源激活。微生物定植和生物膜形成仍然是牙科和制药工业、卫生保健和公共住宿以及船舶利用对人类健康和产品质量的主要成本和威胁。含水液体可消化产品的不透明运输和储存容器的腔面杀菌防污涂层技术的成功开发，构成了一个重要的市场。

This Small Business Innovation Research (SBIR) Phase I project aims to develop new reagents subject to thermal activation for bonding water-soluble microbicidal polymers and surfactants to the lumen surface of a variety of opaque tubing materials at temperatures compatible with the plastics. Materials have been developed with bulk physical properties needed for transport of water and aqueous mixtures; however, the development of biofilm on the wet surfaces is a continuing serious problem in the dental, pharmaceutical, food processing, and marine transport industries. Surface modification of water lines could decrease the formation of biofilm while retaining the desired bulk properties of the tubing. Photochemistry has been proven commercially successful in enhancing the surface properties of medical devices with radical-based surface modification initiated by RF plasma or ultraviolet light. However, these energy sources are not effective for modification the inner surfaces of 'opaque' tubes such as water lines used with dental units and plastic plumbing in pharmaceutical plants. This project is designed to develop latent-reactive radical generators activatible with external source energy that penetrates these 'opaque' devices. This innovative approach to scheduled activation of radical generators is expected to facilitate the coupling to many 'inert' surfaces that cannot be activated with external light or plasma sources.Microbial colonization and biofilm formation remain a major cost and threat to human health and product quality for dental and pharmaceutical industries, health care and public lodging, and marine vessel utilization. Successful development of microbicidal and antifouling coating technology for the luminal surface of opaque transport and storage vessels for aqueous liquid ingestible products, constitute a significant market.