Proton and Hydride Transfer Reactions involving Organic Ions and Ion Radicals

有了这个更新奖的有机和高分子化学计划支持博士弗农D。犹他州洛根的犹他州州立大学的帕克说。 这项工作将扩展早期的研究，研究自由基阳离子的氢转移反应机制的细节，带正电荷的有机化合物与未成对电子自旋。 这类中间体参与了许多重要的生物酶氧化反应和工业氧化及聚合反应。各种自由基阳离子中C-H键断裂的动力学--通过质子或氢化物转移--将通过电化学和分光光度法（包括停流）进行研究，以确定动力学同位素效应如何取决于反应的结构和程度。 许多这些表面上简单的双分子氢转移反应实际上是通过两个步骤与动力学上重要的中间体发生的，这一假设将通过实验来检验。 预计这项工作将为研究生和博士后学生提供宝贵的经验，并为有机化学界提供基本的使用信息。

With this renewal award the Organic and Macromolecular Chemistry Program supports the work of Dr. Vernon D. Parker at Utah State University in Logan, Utah. The work will extend earlier studies looking into the details of the mechanism of hydrogen transfer reactions from radical cations, positively charged organic compounds with an unpaired electron spin. Intermediates of this type are involved in a number of important biological oxidations by enzymes and industrial oxidation and polymerization reactions.The kinetics of C-H bond cleavage in various radical cations - by either proton or hydride transfer - will be studied by electrochemical and spectrophotometric methods (including stopped-flow) to determine how kinetic isotope effects depend on structure and extent of reaction. The hypothesis that many of these apparently simple bimolecular hydrogen transfer reactions actually take place by two steps with kinetically significant intermediates will be tested by experiments. The work is expected to provide valuable experience to graduate and postdoctoral students, as well as providing fundamental information of use to the organic chemical community.