Resolution of the Kinetics of Bimolecular Organic Reactions in Solution

溶液中双分子有机反应动力学的解析

• 批准号: 0313615
• 负责人: Vernon Parker
• 金额: --
• 依托单位: Utah State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0313615&HistoricalAwards=false
• 关键词: Resolution; Kinetics; Bimolecular; Organic; Reactions

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Vernon D. Parker at Utah State University will continue work carried out over the past five years that employed non-steady-state kinetic methods to show that a number of reactions long believed to take place by simple single-step second-order mechanisms are actually more complex and proceed via kinetically significant reaction intermediates. The non-steady-state kinetic method developed in the previous grant period is based upon the observation that the bimolecular reactions examined thus far all take place by the reversible consecutive second-order mechanism involving kinetically significant reaction intermediates. New mechanistic probes developed will be used to examine SN2, elimination, nucleophilic aromatic substitution, group transfer, and Diels-Alder reactions. The research suggested is expected to greatly increase the understanding of bimolecular organic reaction mechanisms. Results are also expected to correct misconceptions based upon the belief that all of these reactions proceed from reactant to product via a single transition state.The Organic and Macromolecular Chemistry Program in the Chemistry Division supports Professor Vernon D. Parker at Utah State University who will challenge the accepted belief that the bimolecular reactions that are the backbone of Physical Organic Chemistry follow simple single-step mechanisms with single transition states on the reaction coordinate between reactants and products. The cutting-edge research will train undergraduate, graduate and postgraduate students who will take part in state-of-the-art research on projects of general interest. Professor Parker will publish the results of this work in high quality journals as well as present seminars on the results, and publish review articles to bring the results into context. Collaborative projects with US researchers and researchers from abroad will be developed.

在化学系有机动力学项目的支持下，犹他州立大学的弗农·D·帕克教授将继续过去五年来开展的工作，这些工作使用非稳态动力学方法来证明长期以来被认为是通过简单的单步二级机制发生的一些反应实际上更复杂，并通过具有重要动力学意义的反应中间体进行。在前一个授权期中发展的非稳态动力学方法是基于这样的观察，即到目前为止所研究的双分子反应都是通过涉及具有重要动力学意义的反应中间体的可逆连续二级机制进行的。新开发的机理探针将用于研究SN2、消除、亲核芳香族取代、基团转移和Diels-Alder反应。这项研究表明，这一研究有望大大增加对双分子有机反应机理的理解。化学系的有机和大分子化学项目支持犹他州立大学的弗农·D·帕克教授，他将挑战公认的信念，即作为物理有机化学的支柱的双分子反应遵循简单的单步机制，在反应物和产物之间的反应坐标上具有单一的过渡态。尖端研究将培养本科生、研究生和研究生，他们将参与有关普遍感兴趣的项目的最新研究。帕克教授将在高质量的期刊上发表这项工作的结果，并举办关于结果的研讨会，并发表评论文章，将结果纳入背景。将开发与美国研究人员和来自海外的研究人员的合作项目。