Resolution of the Kinetics of Bimolecular Organic Reactions in Solution

在化学系有机动力学项目的支持下，弗农D.犹他州州立大学的帕克将继续进行过去五年的工作，这些工作采用非稳态动力学方法来证明，长期以来被认为是通过简单的单步二级机制发生的许多反应实际上更加复杂，并通过动力学上重要的反应中间体进行。非稳态动力学方法开发的前一个补助期是基于观察到的双分子反应检查到目前为止都发生的可逆连续的二级机制，涉及动力学显着的反应中间体。开发的新的机械探针将用于检查SN 2，消除，亲核芳香取代，基团转移和狄尔斯-阿尔德反应。该研究建议有望大大增加对双分子有机反应机理的理解。 结果也有望纠正误解的基础上，认为所有这些反应进行从反应物到产品通过一个单一的过渡态。有机和大分子化学计划在化学部支持教授弗农D。帕克在犹他州州立大学，他将挑战公认的信念，即双分子反应是物理有机化学的支柱，遵循简单的单步机制，反应物和产物之间的反应坐标上有单一的过渡态。前沿研究将培养本科生，研究生和研究生，他们将参加对普遍感兴趣的项目的最先进的研究。帕克教授将在高质量期刊上发表这项工作的结果，并就结果举办研讨会，并发表评论文章以将结果纳入背景。将与美国研究人员和国外研究人员开展合作项目。

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Vernon D. Parker at Utah State University will continue work carried out over the past five years that employed non-steady-state kinetic methods to show that a number of reactions long believed to take place by simple single-step second-order mechanisms are actually more complex and proceed via kinetically significant reaction intermediates. The non-steady-state kinetic method developed in the previous grant period is based upon the observation that the bimolecular reactions examined thus far all take place by the reversible consecutive second-order mechanism involving kinetically significant reaction intermediates. New mechanistic probes developed will be used to examine SN2, elimination, nucleophilic aromatic substitution, group transfer, and Diels-Alder reactions. The research suggested is expected to greatly increase the understanding of bimolecular organic reaction mechanisms. Results are also expected to correct misconceptions based upon the belief that all of these reactions proceed from reactant to product via a single transition state.The Organic and Macromolecular Chemistry Program in the Chemistry Division supports Professor Vernon D. Parker at Utah State University who will challenge the accepted belief that the bimolecular reactions that are the backbone of Physical Organic Chemistry follow simple single-step mechanisms with single transition states on the reaction coordinate between reactants and products. The cutting-edge research will train undergraduate, graduate and postgraduate students who will take part in state-of-the-art research on projects of general interest. Professor Parker will publish the results of this work in high quality journals as well as present seminars on the results, and publish review articles to bring the results into context. Collaborative projects with US researchers and researchers from abroad will be developed.