POWRE: Pulmonary Nitric Oxide and Adaptation to High-Altitude Hypoxia

一氧化氮是人体产生的一种气体，具有多种功能，包括确保氧气从肺部扩散到血液。该项目将开发并验证一种技术，以测量肺部产生的一氧化氮的数量，已知一氧化氮是合成的主要部位。一氧化氮产生的变化被认为对人们在氧气有限的极端环境中生存的能力有影响，比如在高海拔地区。了解安第斯、西藏和埃塞俄比亚高原数以百万计的高海拔原住民如何适应在严重低氧条件下确保氧气输送，将提高对人类适应极端环境和环境变化过程的认识。这个power项目将为Beall提供培训和技术发展的机会，这是她无法获得的。这一发展和测试阶段将在一个受控的实验室环境中进行，以便在偏远的高海拔地点进行实地研究之前确定该技术。

Nitric oxide is a gas produced by the body to perform many functions, including ensuring the diffusion of oxygen from the lungs to the blood. This project will develop and validate a technique to measure the amount of nitric oxide produced in the lungs, known to be a major site of synthesis. Variation in the production of nitric oxide is thought to have consequences for people's ability to inhabit extreme environments where oxygen is limiting, such as those at high altitudes. Understanding how the millions of high-altitude natives of the Andean, Tibetan and Ethiopian Plateaus have adapted to ensure oxygen delivery under conditions of severe low oxygen will improve knowledge of the processes of human adaptation to extreme environments and to environmental change. This POWRE project will provide Beall the opportunity for training and technique development that she cannot obtain otherwise. This developmental and testing phase will be undertaken in a controlled, laboratory environment in order to establish the technique before undertaking field research in remote, high-altitude sites.