Asymmetric Cycloaddition Methodology for Natural Product Synthesis

本项目探索了多种结构类型天然产物全合成的新策略和新方法。项目的重点是环加成化学，重点放在那些可以呈现不对称。这样，多环产物将以单对映体的形式产生。选择用于合成的靶标取自广泛的天然结构，包括萜烯、生物碱和其他含有碳环和杂环框架的复杂系统。通过这个奖项，有机和大分子化学项目（有机合成）支持俄勒冈州立大学詹姆斯·d·怀特教授的研究。怀特教授从事天然产物的全合成，即从某种天然来源分离出的特定分子，通过一系列化学反应精确地复制出来。在这种努力中所采用的策略和策略决定了这些分子在实验室环境中制备的效率，这通常将决定一种特定物质是否可以大规模生产用于制药或其他用途。

This project explores new strategies and methods for the total synthesis of a variety of structural types of natural products. The emphasis of the project is on cycloaddition chemistry, and the focus is placed upon those that can be rendered asymmetric. In this way, polycyclic products will be produced as single enantiomers. The targets selected for synthesis are taken from the broad palette of naturally occurring structures that includes terpene, alkaloids, and other complex systems containing both carbocyclic and heterocyclic frameworks.With this Award, the Organic and Macromolecular Chemistry Program (Organic Synthesis) supports the research of Professor James D. White of Oregon State University. Professor White is involved in the total synthesis of natural products, wherein specific molecules that have been isolated from some natural source are replicated in exact detail through a series of chemical reactions. The strategies and tactics that one employs in this endeavor determine the efficiency with which these molecules are prepared in a laboratory setting, and this often will determine whether or not a particular substance can be mass-produced for pharmaceutical or other use.