Reactions of Nitroso and Nitrosyl Groups with Metalloporphyrins

俄克拉何马大学的George Richter-Addo受到无机、生物无机和有机金属化学项目的支持，研究亚硝基和亚硝基与金属卟啉的反应。本研究的长期目标是利用X-N=O化合物的光谱学、光谱电化学、结构和电子性质来增加对这类化合物与金属卟啉反应的认识，以及对含有X-N=O组分的金属卟啉反应的认识。将研究亚硝胺和亚硝基芳烃金属卟啉配合物的化学和光谱电化学反应，以及烷基亚硝酸盐和亚硫硝酸盐反式加成卟啉产物的化学反应。重点将放在理解目标化合物的反应化学。虽然N=O是一个小分子，但它具有复杂而重要的化学性质。X-N=O类化合物在生物、工业和生态系统等方面具有重要意义。分子中的-N=O基团可以参与多种不同的化学反应，这取决于与-N=O基团结合的分子的详细性质。继一项成功的研究工作之后，该研究工作表征了各种X-N=O物种的原子和电子结构，包括许多X是具有重要生物学意义的卟啉基团的物种，本项目将重点放在N=O基团在其化合物中所表现出的各种化学反应性上，并试图阐明这些反应模式如何受到原子和电子结构的影响。获得这种理解的进展将对涉及X-N=O化合物的所有许多领域的科学和技术产生重要影响。

George Richter-Addo of the University of Oklahoma is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for research on the reactions of nitroso and nitrosyl groups with metalloporhyrins. The long-term goal of the research is to use spectroscopic, spectroelectrochemical, structural and electronic properties of X-N=O compounds to increase understanding of reactions of such compounds with metalloporphyrins, and of the reactions of metalloporphyrins containing X-N=O components. Chemical and spectroelectrochemical reactions of metalloporphyrin complexes of nitrosamines and nitrosoarenes will be investigated as well as the chemistry of products that result from trans additions of alkyl nitrites and thionitrites to porphyrins. Emphasis will be placed on understanding the reaction chemistry of the target compounds.Although N=O is a small molecule it has a complex and important chemistry. Compounds of the X-N=O sort are of central importance in biological, industrial and ecological systems, among others. The -N=O grouping in molecules can participate in a wide variety of diverse chemical reactions, depending on the detailed nature of the molecules in which the -N=O group is bound. Following up on a successful research effort that has characterized the atomic and electronic structures of a variety of X-N=O species, including many in which X has been the biologically important porphyrin grouping, the present program focuses on the various types of chemical reactivity that are exhibited by the N=O grouping in its compounds, and seeks to elucidate how those reactivity-patterns are influenced by atomic and electronic structure. Progress in gaining such understanding would have important consequences for science and technology in all the many areas in which X-N=O compounds are involved.