Multi-scale Mechanics Analysis of Bone Remodeling in Normal vs. Osteoporotic Trabecular Bone

0085137我们将从力学的角度解决松质骨的重建问题。为了了解力学因素如何影响这一过程，我们将在细胞水平上预测发生骨重建的局部应力和应变场。我们特别感兴趣的是健康骨骼和骨质疏松骨骼之间的区别。通过了解这两种类型的骨在相同的外载荷下的局部场，我们希望确定健康骨和骨质疏松骨的机械载荷与骨改建的关系。我们的分析将解释骨骼的等级性质，并将涉及理论和实验。

0085137We will address remodeling in trabecular bone from a mechanical viewpoint. In order to understand how mechanical factors contribute to this process we will predict local stress and strain fields at the cellular level where bone remodeling takes place. In particular we are interested in differences between healthy and osteoporotic bones. By knowing local fields in these two types of bone, under the same external loads, we hope to determine relations between mechanical load and bone remodeling in healthy and osteoporotic bone. Our analysis will account for the hierarchical nature of bone and will involve both theory and experiments.