CAREER: Bioinorganic Chemistry of Nitrogen/Sulfur Ligands Possessing Internal Hydrogen Bond Donors

犹他州州立大学化学系的Lisa Berreau博士获得了国家科学基金会化学部无机、生物无机和有机金属化学项目的支持，以表彰她将开发一类新的含有氢键供体的螯合氮/硫配体的工作。氢氧化锌、醇盐和碳酸氢盐通过内部氢键稳定的配合物将被合成和表征，以确定几种金属酶的结构/功能关系，从而设计用于醇的氧化、二氧化碳的水合和酰胺的水解裂解的新催化剂。在教育方面，将发展一门利用合作学习技术的新生物无机化学课程，以及两门同样包含生物无机化学元素的新本科实验室课程。学生将接受基础广泛的无机化学培训，对生物系统的化学有重要的见解。将开发的催化剂具有重要的技术意义。

Dr. Lisa Berreau, Department of Chemistry, Utah State University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program, Division of Chemistry, National Science Foundation, through a Career Award for her work in which a new class of chelating nitrogen/sulfur ligands containing hydrogen bond donors will be developed. Complexes with zinc hydroxide, alkoxide and bicarbonate stabilized by internal hydrogen-bonds will be synthesized and characterized to determine structure/function relationships for several metalloenzymes toward design of new catalysts for the oxidation of alcohols, hydration of carbon dioxide, and hydrolytic cleavage of amides. In the educational front, a new bioinorganic chemistry course utilizing cooperative learning techniques, and two new undergraduate laboratory courses also incorporating bioinorganic chemistry elements will be developed.Students will receive a broad-based training in inorganic chemistry with significant insights into the chemistry of biological systems. The catalysts that will be developed are of technological importance.