NIRT/GOALI: DNA-Based Nanomechanical Devices

摘要CTS-0103002 N。Seeman等人，纽约大学这一建议是在响应纳米科学与工程（NSE）招标，NSF-00119，在类别纳米跨学科研究团队（NIRT）。 这是纽约大学、加州理工学院和陶氏化学公司采用GOALI模式的合作活动。 目标是合成和演示可操作的纳米机器或设备。DNA系统提供的控制水平可以用来制造复杂的DNA纳米结构，包括形成二维和三维阵列的自组装DNA。 建模和仿真是该项目的关键部分，以构建和测试DNA纳米结构。建议将联合收割机与纽约大学、加州理工学院和陶氏化学实验室的活动结合起来，以实现基于DNA的纳米机械装置的演示，该装置可用于执行快速计算、用于检测环境中特定分子的传感器或用于改善材料的性质或性能。 纳米机器和器件的实际设计和制造需要克服合成、加工、表征、设计、优化和制造中的众多挑战。 该方法将首先通过计算对设计进行原型设计，优化特定的碱基对序列，确保特定的长度和间距将导致适当的间隙，并测试设备的操作，包括动力学。 该项目将重点关注三种类型的纳米机械设备。〇基于B-Z的纳米粒子。 一种基于DNA在不同盐条件下从B到Z DNA的转变的纳米晶体。 基于类似于DNA序列特异性机械装置的原理的基于DNA的开关。

AbstractCTS-0103002N. Seeman, et al., New York UniversityThis proposal was received in response to Nanoscale Science and Engineering (NSE) solicitation, NSF-00119, in the category Nanoscale Interdisciplinary Research Teams (NIRT). This is a collaborative activity between New York University, California Institute of Technology and Dow Chemical Co. using GOALI model. The goal is to synthesize and demonstrate operational nanoscale machines or devices. The level of control offered by DNA systems can be exploited to make intricate DNA nanostructures, including self-assembling DNA that forms two-dimensional and three-dimensional arrays. Modeling and simulation is a critical part of this project, in order construct and test the DNA nanostructures. It is proposed to combine the activities of New York University, California Institute of Technology and Dow Chemical laboratories to achieve a demonstration of DNA based nanomechanical devices useful for performing fast calculations, for sensors that detect specific molecules in the environment, or to improve the properties or performance of a material. Practical design and manufacture of nanoscale machines and devices requires overcoming numerous challenges in synthesis, processing, characterization, design, optimization, and fabrication. The approach will be first to prototype the designs computationally, optimizing the particular base-pair sequences, making sure that the particular lengths and spacings will lead to proper clearances, and testing the operation of the device, including the dynamics. The project will focus on nanomechanical devices of three types. o The B-Z based nanomotor. A DNA based nanomotor predicated on the B to Z DNAtransitions under different salt conditions. o A DNA sequence-specific mechanical device o A DNA based switch based on principles similar to the DNA sequence-specific mechanical device.