Support for the Center for BioDynamics at Boston University

研究者和她的同事在生物动力学中心（CBD）的一个小组项目中合作，在一个充满活力的跨学科研究项目的背景下，为研究生和博士后水平的研究人员提供跨学科的教育和培训，该研究项目集中在数学（特别是动力系统）、生物学和工程学等共同感兴趣的领域。学科包括数学、生物医学工程、航空航天/机械工程、生物学、心理学和物理学。培训超出了通常的课堂活动，参与者也参与了各种研究项目。其中一个主要的主题是神经系统的动力学。这些项目包括实验、建模和分析，都涉及神经系统中各种各样的节奏，以及这些节奏在关键认知状态和过程（如注意力、意识、学习和回忆）中的潜在功能。第二个主要主题是基因表达的动力学。基因组研究的进展导致了生物学构建模块的图谱，并推动了基因调控的研究，其中蛋白质通常在复杂的相互作用网络中调节自己或其他蛋白质的生产。生物多样性研究项目的重点是利用非线性动力学、统计物理、控制理论和分子生物学等技术对合成的调节网络进行建模、设计和构建，并对自然发生的调节网络进行探索。第三个主要主题是模式和波浪的动力学。培训活动包括每周两次的工作研讨会，额外的期刊俱乐部和阅读小组，向CBD成员介绍中心内正在进行的研究的研讨会，以及由CBD发起的团队授课课程。生物动力学中心（CBD）有助于促进对数学、生物学和工程学交叉领域的跨学科难题的理解，并为21世纪的劳动力培养数学家、科学家和工程师。它通过将传统的课堂教育与学生和博士后在跨学科团队中对当前问题的大量参与相结合来实现这一目标。涉及的学科包括数学、生物医学工程、航空航天/机械工程、生物学、心理学和物理学。其中一个主要的主题是神经系统的动力学。这个主题的项目试图阐明大脑中电活动的起源，以及大脑如何利用这种活动来处理感觉信息、思考和调节运动。第二个主要主题是基因表达的动力学。由基因产生的蛋白质相互作用的网络是复杂的；与本主题相关的项目涉及人工调控网络的设计和构建，以及更好地理解自然发生的基因调控网络的技术。第三个主要主题是在各种应用程序中出现的模式和波的动力学。培训活动包括每周两次的工作研讨会，定期阅读科学期刊，向CBD成员介绍中心内正在进行的研究的研讨会，以及由CBD发起的团队授课课程。该项目由计算数学、应用数学、计算神经科学和生物数据库与信息学项目以及MPS多学科活动办公室支持。

The investigator and her colleagues collaborate in a groupproject at the Center for BioDynamics (CBD) to provideinterdisciplinary education and training for graduate studentsand postdoctoral-level investigators in the context of a vigorousinterdisciplinary research program that focuses on areas ofmutual interest in mathematics (especially dynamical systems),biology, and engineering. Disciplines include mathematics,biomedical engineering, aerospace/mechanical engineering,biology, psychology, and physics. Training extends beyond theusual classroom activities by engaging participants in a varietyof research projects as well. One of the major topics is dynamicsof the nervous system. The projects, which involve experiments,modeling, and analysis, all deal with the variety of rhythms inthe nervous system and the potential functions of these rhythmsin key cognitive states and processes such as attention,awareness, learning, and recall. A second major topic isdynamics of gene expression. Progress in genomic research isleading to maps of the building blocks of biology and fueling thestudy of gene regulation, where proteins often regulate their ownproduction or that of other proteins in a complex web ofinteractions. CBD projects focus on using techniques fromnonlinear dynamics, statistical physics, control theory, andmolecular biology to model, design, and construct synthetic generegulatory networks, and to probe naturally occurring generegulatory networks. The third major topic is the dynamics ofpatterns and waves. Training activities include two weeklyworking seminars, extra journal clubs and reading groups,seminars to educate the CBD members in the research going onwithin the Center, and a CBD-initiated team-taught course. The Center for BioDynamics (CBD) helps to advanceunderstanding of difficult interdisciplinary problems at theintersection of mathematics, biology, and engineering, and ittrains mathematicians, scientists, and engineers for the 21stcentury workforce. It does this by combining traditionalclassroom education with significant engagement of students andpostdocs in interdisciplinary teams working on current problems.The disciplines involved are mathematics, biomedical engineering,aerospace/mechanical engineering, biology, psychology, andphysics. One of the major topics is dynamics of the nervoussystem. The projects in this topic seek to shed light on theorigin of the electrical activity in the brain, and how the brainuses this activity to process sensory information, to think, andto regulate movement. A second major topic is dynamics of geneexpression. The web of interactions among the proteins that areproduced by genes is complex; the projects associated with thistopic involve the design and construction of artificial generegulatory networks, and techniques to better understandnaturally occurring gene regulatory networks. The third majortopic is the dynamics of patterns and waves, occuring in avariety of applications. Training activities include two weeklyworking seminars, regular sessions to read scientific journals,seminars to educate the CBD members in the research going onwithin the Center, and a CBD-initiated team-taught course. Theproject is supported by the Computational Mathematics, AppliedMathematics, Computational Neuroscience, and Biological Databasesand Informatics programs and by the MPS Office ofMultidisciplinary Activities.