SGER: Collaborative Research: Cognitive Rhythms Collaborative, A Discovery Network

SGER：协作研究：认知节律协作，发现网络

• 批准号: 0848469
• 负责人: Nancy Kopell
• 金额: --
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-10-01 至 2010-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848469&HistoricalAwards=false
• 关键词: SGER; Collaborative; Research; Cognitive; Rhythms

This project focuses on the functional implications of low-frequency rhythms in the basal ganglia and neocortex. The collaborative effort involves four groups: Kopell, (Boston University), Moore (Massachusetts Institute of Technology), Graybiel (Massachusetts Institute of Technology) and Boyden (Massachusetts Institute of Technology). The project is the first collaborative research effort of the newly formed Cognitive Rhythms Collaborative (CRC), a group of Boston Area faculty members from Boston University, Massachusetts Institute of Technology, Massachusetts General Hospital Martinos Center for Biomedical Imaging, Brandeis University and Tufts University. The aims of the CRC, which fosters research and training, are to map the spatio-temporal structure of brain dynamics and connect these dynamics to brain function. This is the first project to try to understand from basic electrophysiology the growing literature suggesting that the low frequency brain rhythms are critical for both attention and learning, and that interactions among brain structures such as the basal ganglia and neocortex are central for such functions. The project makes use of the electrophysiology skills of the Graybiel lab, which is focused on the dynamics of the basal ganglia, and those of the Moore lab, focused on the neocortex, to understand the flow of information between the cortex and the basal ganglia during learning and attention. This collaboration is enriched by new molecular biology technology developed by the Boyden group. This technology, in which cells can be activated and inactivated by light, provides powerful new techniques for figuring out circuits by looking at effects of perturbations, even in behaving animals. The experimental work is guided by modeling ideas from the Kopell and Moore labs, and the output of the modeling can be tested almost immediately by the labs for quick feedback and changes. This CRC project exemplifies a new and transformational way of doing science, bridging the boundaries of disciplines and institutes to facilitate cutting edge research at the forefront of interdisciplinary endeavors.

这个项目的重点是在基底神经节和新皮层的低频节律的功能意义。这项合作涉及四个小组：科佩尔（波士顿大学）、摩尔（马萨诸塞州理工学院）、格雷比尔（马萨诸塞州理工学院）和博伊登（马萨诸塞州理工学院）。该项目是新成立的认知节律合作组织（CRC）的第一个合作研究成果，该组织由波士顿大学、马萨诸塞州理工学院、马萨诸塞州总医院、马丁诺斯生物医学成像中心、布兰迪斯大学和塔夫茨大学的波士顿地区教师组成。CRC的目标是促进研究和培训，绘制大脑动力学的时空结构，并将这些动力学与大脑功能联系起来。这是第一个试图从基本电生理学理解的项目，越来越多的文献表明，低频脑节律对注意力和学习都至关重要，并且大脑结构（如基底神经节和新皮层）之间的相互作用对这些功能至关重要。该项目利用Graybiel实验室的电生理学技能，专注于基底神经节的动力学，以及摩尔实验室专注于新皮层的电生理学技能，以了解学习和注意力过程中皮层和基底神经节之间的信息流。Boyden集团开发的新分子生物学技术丰富了这种合作。这项技术可以通过光激活和灭活细胞，提供了强大的新技术，通过观察扰动的影响来找出电路，即使是在行为动物中。实验工作由Kopell和摩尔实验室的建模思想指导，实验室几乎可以立即测试建模的输出，以获得快速反馈和更改。这个CRC项目体现了一种新的和变革性的科学方法，弥合学科和研究所的界限，以促进跨学科努力前沿的前沿研究。