Scripps Center for Oceans and Human Health: advancing the science of marine contaminants and seafood security

斯克里普斯海洋与人类健康中心(SCOHH)是一项为期五年的努力，旨在推动围绕海鲜污染物的科学和社区参与，在一个快速变化的星球上。该项目汇集了一支由生物医学和海洋研究人员组成的多学科团队，他们拥有鱼类生态学、微生物学、海洋化学、气候建模、技术开发、生物积累、基因组学、毒理学和公共卫生方面的专业知识。该中心的科学目标和重点是以社会需求为导向，通过双向社区参与建立起来的，并由经过验证的社区参与团队领导。SCOHH的拟议研究计划涵盖四个主要领域：1.气候变化对人类摄取海鲜微量营养素和污染物的影响。2.作为海产品污染物合成、转化和分布来源的海洋微生物群。3.海产品污染物的生物累积和发育毒性机制。4.围绕海产品风险和利益的双向公众参与和识字。SCOHH的结果将为降低海产品消费风险和提高与海产品消费相关的更大利益的政策、消费指南和个人决策提供参考。在内部，SCOHH将采取深思熟虑的措施，从研究团队和研究生/博士后实习生到与社区合作伙伴的接触，在其运作的各个方面加强公平、多样性和包容性。该中心由NSF海洋科学部和国家环境健康科学研究所(NIEHS)共同支持。SCOHH的中心科学主题是促进海洋污染物和海产品安全的知识。自然和人为污染物，如汞、滴滴涕和多氯联苯，推动了海鲜消费建议。然而，对它们的来源、微生物转化、毒性和气候驱动变化的可能性的了解仍然不完整。SCOHH团队将研究和跟踪海洋食物网中必需的微量营养素和有害污染物在全球30亿消费海鲜的人中的分布，海洋微生物在其生产和运输中所扮演的角色，以及海鲜污染物的发育毒性及其与决定吸收和生物累积的转运体的相互作用。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The Scripps Center for Oceans and Human Health (SCOHH) is a five-year effort to advance the science and community engagement surrounding seafood pollutants, on a rapidly changing planet. The project brings together a multidisciplinary team of biomedical and oceanographic researchers with expertise in fish ecology, microbiology, marine chemistry, climate modeling, technology development, bioaccumulation, genomics, toxicology, and public health. The Center’s scientific goals and focus are guided by the needs of society, established through bidirectional community engagement, and led by a proven community engagement team. The proposed research program of SCOHH spans four main areas:1. Climate change impacts on the human intake of seafood micronutrients and contaminants. 2. The marine microbiome as a source for the synthesis, transformation, and distribution of seafood contaminants. 3. Mechanisms of bioaccumulation and developmental toxicity of seafood pollutants. 4. Bidirectional public engagement and literacy surrounding seafood risks and benefits.The outcomes of the SCOHH will inform policies, consumption guidelines, and individual decisions to lower risk and enhance greater benefits associated with seafood consumption. Internally, SCOHH will take deliberate measures to enhance equity, diversity, and inclusion in all aspects of its functioning, from the investigator team and graduate student/postdoctoral trainees to engagement with community partners. The Center is jointly supported by NSF’s Division of Ocean Sciences and by the National Institute for Environmental Health Sciences (NIEHS).The central scientific theme of SCOHH is to advance knowledge of marine contaminants and seafood security. Natural and anthropogenic contaminants such as mercury, DDT, and PCBs drive seafood consumption advisories. Yet understanding of their sources, microbial transformations, toxicity, and potential for climate driven change remain incomplete. The SCOHH team will study and track the distribution of essential micronutrients and harmful contaminants in marine food webs to the three billion people who consume seafood globally, the roles that the marine microbiome play in their production and transport, and the developmental toxicity of seafood pollutants and their interactions with transporters that determine uptake and bioaccumulation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.