Mechanisms of Transition Metal Catalyzed Reactions in Hydrocarbons

本项目继续探索有机金属烯烃复分解反应，这已经成长为现代合成化学家的关键工具之一。应用包括小分子的合成，如天然产物，以及具有明确结构和控制性能的聚合物的生产。在目前的拨款期间，重点将放在更充分地了解这些反应的基本机制基础。除了其内在的科学价值外，预计这些研究还将进一步改进和开发新的催化剂系统。将开环复分解与原子转移自由基聚合相结合的串联策略应用于生产各种新型聚合物结构，如梳状和超支化体系。通过这个奖项，化学学部的有机和大分子化学项目以及材料研究部的固态化学和聚合物项目支持了加州理工学院Robert H. Grubbs教授的研究活动。Grubbs教授开发了非常强大的催化剂，用于精确构建有机分子，包括那些对制药和聚合物工业感兴趣的催化剂。目前的资助期将允许进一步了解和改进所需的催化剂系统，以及它们在制备新型聚合物物质中的应用。

This project continues the exploration of organometallic olefin metathesis reactions, which has grown into one of the key tools of modern synthetic chemists. Applications include the synthesis of small molecules, such as natural products, and the production of polymers with well-defined structures and controlled properties. During the current granting period, emphasis will be placed on developing a fuller understanding of the fundamental mechanistic underpinnings of these reactions. Further refinement and development of new catalyst systems are expected to accrue from such studies, in additional to their intrinsic scientific value. Applications of a tandem strategy coupling ring-opening metathesis with atom transfer radical polymerization will be used to produce a variety of new polymer structures such as comb and hyper-branched systems.With this Award, the Organic and Macromolecular Chemistry Program of the Division of Chemistry and the Solid State Chemistry and Polymers Program of the Division of Materials Research support the research activities of Professor Robert H. Grubbs of the California Institute of Technology. Professor Grubbs has developed very powerful catalysts for the precise construction of organic molecules including those of interest to the pharmaceutical and polymer industries. The current period of funding will allow for the further understanding and refinement of the needed catalyst systems as well as their applications for the preparation of novel polymeric substances.