Applied Drug Delivery Throughout the Engineering Curriculum

药物递送是一个新兴的领域，代表了当今制药行业的主要研究和开发重点领域之一，每年新药物递送系统的销售额超过100亿美元。化学工程师在这个令人兴奋的领域发挥着重要和不断扩大的作用，但本科化学工程专业的学生很少通过他们的课程接触药物输送。为了向学生提供与制药行业不断发展的需求直接相关的技能，该项目正在开发和整合应用药物输送课程和实验，整个罗文工程课程。设计和生产新的药物输送系统要求工程师充分了解药物，并了解与影响药物释放的加工变量相关的材料特性。这就要求工程师对传质、反应动力学、热力学和传输现象的基本原理有扎实的掌握。他或她还必须熟练掌握表征技术和输送系统的物理性能测试，并在药物释放数据的分析方面进行实践。该项目为罗文大学化学工程专业的学生提供了必要的基础材料和基本原理。有七个模块适应，实施和用于向学生介绍常见药物输送系统设计的多学科工程原理。每个模块描述了用于支持该特定药物输送系统的设计，制备，表征和分析的实验。探索的七种药物递送系统是：片剂、软膏剂、膜系统、微胶囊、渗透泵、化学动力学和超临界流体处理的颗粒。该项目的工程目标是：--探索不同类型的药物输送系统--利用工程原理以定量的方式研究药物输送设计--使用最新的工业技术来生产、测试和分析药物输送系统，并评估影响药物从输送系统释放的因素。为了实现这些目标，该合作项目通过垂直整合从新生诊所开始的七个模块，其次是基础工程课程，初中-高中研究项目课程，最后是关于制药主题的高级选修课程，从而最大限度地发挥课程的影响。这些单元采用了中小型企业和技术教育中行之有效的方法。为了保持质量，高级项目人员和其他化学工程系教师的定期会议是必要的。该项目正在进行形成性评价和总结性评价，并通过在国家会议上的介绍、光盘和经评审的期刊来传播该项目。关键词：药物传递系统，药物传递方法，药物传递系统

Drug Delivery is a burgeoning field that represents one of the major research and development focus areas of the pharmaceutical industry today, with new drug delivery system sales exceeding 10 billion dollars per year. Chemical Engineers play an important and expanding role in this exciting field, yet undergraduate chemical engineering students are rarely exposed to drug delivery through their coursework. To provide students with the skills directly relevant to the evolving needs of the pharmaceutical industry, this project is developing and integrating applied drug delivery coursework and experiments throughout the Rowan Engineering curriculum. The design and production of new drug delivery systems requires that the engineer fully understand the drug and know material properties related to the processing variables that affect the release of the drug. This requires the engineer to have a solid grasp of the fundamentals of mass transfer, reaction kinetics, thermodynamics, and transport phenomena. He or she must also be skilled in characterization techniques and physical property testing of the delivery system, and practiced in the analysis of the drug release data. This project provides the Chemical Engineering students at Rowan University with the necessary foundation materials and fundamental principles. There are seven modules adapted, implemented and used to introduce students to the multidisciplinary engineering principles of common drug delivery systems designs. Each module describes experiments used to support the design, preparation, characterization, and analysis of that particular drug delivery system. The seven drug delivery systems explored are: tablets, ointments, membrane systems, microcapsules, osmotic pumps, Chemical kinetics, and supercritical fluid-processed particles. The engineering goals of this project are:--to explore different types of drug delivery systems--to study drug delivery designs in a quantitative manner using engineering principles--to use up-to-date industrial techniques for the production, testing, and analysis of drug delivery systems and to evaluate factors influencing the release of drug from a delivery system.To accomplish these goals, this collaborative project maximizes the curricular impact by vertically integrating the seven modules beginning with the Freshman Clinic, followed by the fundamental engineering courses, the Junior-Senior research projects course, and finally, advanced level elective courses on pharmaceutical topics. These modules employ proven methods in SMET education. To maintain the quality , recurring meetings of senior project personnel and other Chemical Engineering Department faculty are planned as necessary. The project is undertaking both formative evaluations and summative evaluations, and its dissemination is being accomplished through presentations at national conferences, CD-ROM and refereed journals. Keywords: Drug delivery systems, drug delivery methods, pharmaceutical drug delivery systems