CAREER: New Ligand Templates for Asymmetric Catalysis

本研究的重点是开发一种手性恶唑啉的一般合成方法，该方法可用于发现以分子氧为末端氧化剂的对映选择性烯烃环氧化催化剂。此外，将寻求用于不对称烯丙基置换的手性吡啶配体的一般合成。该项目的教育重点是将合成有机化学的当前应用与基础物理有机化学的关系纳入课程。通过这项职业建议，有机和大分子化学计划支持犹他大学化学系马修·西格曼博士的研究和教学工作。西格曼教授将专注于开发用于不对称合成的新型手性配体。配体将以系统的方式组装，以便优化和直接了解反应机制。这种类型的方法发展为制药和农业工业提供了机会。西格曼博士的教学活动将集中于改进有机化学课程。

The focus of this research is to develop a general synthesis of chiral oxazolines, which can be applied to the discovery of enantioselective olefin epoxidation catalysts using molecular oxygen as a terminal oxidant. Further, a general synthesis of chiral pyridine ligands for application to an asymmetric allylic displacement will be sought. The educational focus of the project is to incorporate, into the curriculum, the relationship of current applications in synthetic organic chemistry to the fundamentals physical organic chemistry.With this CAREER proposal, the Organic and Macromolecular Chemistry Program is supporting the research and teaching efforts of Dr. Matthew Sigman of the Department of Chemistry at the University of Utah. Professor Sigman will focus his work on developing new chiral ligands for applications in asymmetric synthesis. The ligands will be assembled in a systematic manner in order to allow for optimization and direct insight into reaction mechanisms. This type of methodology development presents opportunities for the pharmaceutical and agricultural industries. Dr. Sigman's educational activities will be focused on improving the organic chemistry curriculum.